Electronic Resource
More than movement: the proprioceptive system as a new regulator of musculoskeletal biology
| العنوان: | More than movement: the proprioceptive system as a new regulator of musculoskeletal biology |
|---|---|
| المؤلفون: | Bornstein, B, Konstantin, N, Alessandro, C, Tresch, M, Zelzer, E, Bornstein B, Konstantin N, Alessandro C, Tresch MC, Zelzer E |
| بيانات النشر: | Elsevier BV country:NL 2021 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The proprioceptive system is essential for the control of coordinated movement and posture. Thus, traditionally, the study of proprioception has focused on its role in motor control. In this review, we present more recent findings on other, non-traditional functions of this system. We focus on its involvement in musculoskeletal development, function and pathology, including the regulation of spinal alignment, bone fracture repair and joint morphogenesis. We present the hypothesis that the proprioceptive system plays a central role in musculoskeletal biology, and that understanding the underlying molecular mechanisms will promote both basic science and medical innovations. As an example, we discuss recent evidence indicating that Piezo2, a key mechanosensitive ion channel of proprioception, regulates spine alignment and joint development. The presented findings show that the proprioceptive system regulates a wide range of developmental and physiological processes and that its dysfunction may contribute to the etiology of various musculoskeletal pathologies. |
| مصطلحات الفهرس: | motor control, p'roprioception, muscle coordination, joint loading, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/wos/WOS:000637691700012 volume:20 firstpage:77 lastpage:89 numberofpages:13 journal:CURRENT OPINION IN PHYSIOLOGY |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/closedAccess |
| ملاحظة: | ELETTRONICO English |
| Other Numbers: | ITBAO oai:boa.unimib.it:10281/392282 10.1016/j.cophys.2021.01.004 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099794094 1346403468 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1346403468 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |