Electronic Resource
Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms
| العنوان: | Olanzapine poisoning in patients treated at the National Poison Control Centre in Belgrade, Serbia in 2017 and 2018: a brief review of serum concentrations and clinical symptoms |
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| Additional Titles: | Teška trovanja olanzapinom – analitički podatci Nacionalnoga centra za kontrolu trovanja u Beogradu u dvogodišnjem razdoblju |
| المؤلفون: | Đorđević, Snežana, Perković Vukčević, Nataša, Antunović, Marko, Kilibarda, Vesna, Vuković Ercegović, Gordana, Jović Stošić, Jasmina, Vučinić, Slavica |
| المصدر: | Arhiv za higijenu rada i toksikologiju; ISSN 0004-1254 (Print); ISSN 1848-6312 (Online); Volume 73; Issue 2 |
| بيانات النشر: | Institute for Medical Research and Occupational Health 2022 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Olanzapine is a thienobenzodiazepine class antipsychotic that strongly antagonises the 5-HT2A serotonin receptor, but acute poisonings are reported rarely. Symptoms of an overdose include disorder of consciousness, hypersalivation, myosis, and coma. Serum concentration higher than 0.1 mg/L is toxic, while concentration above 1 mg/L can be fatal. Here we report key data about 61 patients admitted to the National Poison Control Centre in Belgrade, Serbia over olanzapine poisoning in 2017 and 2018. The ingested doses ranged from 35 to 1680 mg, and time from ingestion to determination from two to 24 hours. In 34 patients olanzapine serum concentrations were in the therapeutic range and in 27 in the toxic range. In five patients they were higher than fatal, but only one patient died. The most common symptoms of poisoning were depressed consciousness (fluctuating from somnolence to coma), tachycardia, hypersalivation, hypotension, myosis, and high creatine kinase. All patients but one recovered fully after nonspecific detoxification and symptomatic and supportive therapy. Olanzapin je antipsihotik koji pripada grupi tienobenzodiazepina. Kao i drugi atipični antipsihotici, olanzapin je jak antagonist 5-HT2A serotoninskih receptora. Akutna trovanja olanzapinom su rijetka. Simptomi predoziranja uključuju duboki ili fluktuirajući poremećaj stanja svijesti s hipersalivacijom i miozom, kao i komu i smrt u slučaju ingestije velikih doza. Koncentracije olanzapina u serumu veće od 0,1 mg/L smatraju se toksičnima, a letalnima veće od 1 mg/L. U radu su prikazana akutna trovanja olanzapinom zabilježena u Nacionalnom centru za kontrolu trovanja u Beogradu tijekom dvije godine. Koncentracije olanzapina u serumu pacijenata akutno otrovanih olanzapinom određene su pouzdanom metodom tekuće kromatografije s masenom spektrometrijom. Registriran je 61 pacijent s predoziranjem olanzapinom: u njih 34 koncentracije olanzapina bile su u terapijskom opsegu, a u njih 27 zabilježene su toksične koncentracije. Pet pacijenata imalo je koncentracije veće od letalnih, a zabilježen je i jedan smrtni ishod. Najčešći simptomi trovanja bili su hipotenzija, tahikardija i povećanje aktivnosti enzima kreatin kinaze. Nakon primjene nespecifičnog detoksikacijskog simptomatskog i potpornog liječenja svi pacijenti osim jednog su se potpuno oporavili. |
| مصطلحات الفهرس: | liquid chromatography mass spectrometry; overdose; serum concentration; therapy; thienobenzodiazepines, predoziranje; serumska koncentracija; tekućinska kromatografija-spektrometrija masa; terapija, text, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | info:eu-repo/semantics/altIdentifier/doi/10.2478/aiht-2022-73-3635 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess Copyright: Institute for Medical Research and Occupational Health, Zagreb, Croatia Parts of the contents such as figures and tables may be reproduced without prior permission, provided reference is made to the source. Annual subscription to the printed version (postage included): Europe Eur 70.00; overseas countries Eur 85,00 Slovenian Society of Toxicology Eur 30.00 Full text articles online available for free. |
| ملاحظة: | application/pdf English Croatian |
| Other Numbers: | HRCAK oai:hrcak.srce.hr:279720 1337413804 |
| المصدر المساهم: | HRCAK PORTAL ZNANSTVENIH CASOPISA REPUB From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1337413804 |
| قاعدة البيانات: | OAIster |
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