Electronic Resource
Masaoka-koga and tnm staging system in thymic epithelial tumors: Prognostic comparison and the role of the number of involved structures
| العنوان: | Masaoka-koga and tnm staging system in thymic epithelial tumors: Prognostic comparison and the role of the number of involved structures |
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| المؤلفون: | Chiappetta, M., Lococo, Filippo, Pogliani, L., Sperduti, I., Tabacco, Diomira, Bria, Emilio, D'Argento, Ettore, Massaccesi, Mariangela, Boldrini, Luca, Meacci, Elisa, Porziella, Venanzio, Nachira, Dania, Congedo, Maria Teresa, Margaritora, Stefano, Lococo F. (ORCID:0000-0002-9383-5554), Tabacco D., Bria E. (ORCID:0000-0002-2333-704X), D'argento E., Massaccesi M., Boldrini L., Meacci E. (ORCID:0000-0001-8424-3816), Porziella V. (ORCID:0000-0001-6000-3172), Nachira D. (ORCID:0000-0003-2937-9678), Congedo M. T., Margaritora S. (ORCID:0000-0002-9796-760X) |
| بيانات النشر: | MDPI 2021 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: The aim of this study was to evaluate the Masaoka–Koga and the tumor node metastases (TNM) staging system in thymic epithelial tumors (TET) considering possible improvements. Methods: We reviewed the data of 379 patients who underwent surgical resection for TET from 1 January 1985 to 1 January 2018, collecting and classifying the pathological report according to the Masaoka–Koga and the TMN system. The number of involved organs was also considered as a possible prognostic factor and integrated in the two staging systems to verify its impact. Results: Considering the Masaoka–Koga system, 5-and 10-year overall survival (5–10YOS) was 96.4% and 88.9% in stage I, 95% and 89.5% in stage II and 85.4% and 72.8% in stage III (p = 0.01), with overlapping in stage I and stage II curves. Considering the TNM system, 5–10YOS was 95.5% and 88.8% in T1, 84.8% and 70.7% in T2 and 88% and 76.3% in T3 (p = 0.02), with overlapping T2– T3 curves. Including the number of involved structures, in Masaoka–Koga stage III, patients with singular involved organs had a 100% and 76.6% vs. 87.7% 5–10YOS, which was 76.6% in patients with multiple organ infiltration. Considering the TNM, T3 patients with singular involved structures presented a 5–10YOS of 100% vs. 62.5% and 37.5% in patients with multiple organ involvement (p = 0.07). Conclusion: The two staging systems present limitations due to overlapping curves in early Masaoka–Koga stages and in advanced T stages for TNM. The addition of the number of involved organs seems to be a promising factor for the prognosis stratification in these patients. |
| مصطلحات الفهرس: | Masaoka–Koga, Surgery, Thymic carcinoma, Thymoma, TNM, Settore MED/21 - CHIRURGIA TORACICA, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/34771417 info:eu-repo/semantics/altIdentifier/wos/WOS:000719217100001 volume:13 issue:21 firstpage:5254 lastpage:N/A issueyear:2021 journal:CANCERS |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | SYC oai:publicatt.unicatt.it:10807/201680 10.3390/cancers13215254 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85117331637 1330709914 |
| المصدر المساهم: | UNIV CATTOLICA DEL SACRO CUORE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1330709914 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |