Electronic Resource
The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity?
| العنوان: | The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity? |
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| المؤلفون: | UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SST/LIBST - Louvain Institute of Biomolecular Science and Technology, UCL - (SLuc) Service de biochimie médicale, Pavan, Cristina, Delle Piane, Massimo, Gullo, Maria, Filippi, Francesca, Fubini, Bice, Hoet, Peter, Horwell, Claire J, Huaux, François, Lison, Dominique, Lo Giudice, Maria, Martra, Gianmario, Montfort, Eliseo, Schins, Roel, Sulpizi, Marialore, Wegner, Karsten, Wyart-Remy, Michelle, Ziemann, Christina, Turci, Francesco |
| المصدر: | Particle and fibre toxicology, Vol. 16, no. 1, p. 32 [1-10] (2019) |
| بيانات النشر: | BioMed Central 2019 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: Silica continues to represent an intriguing topic of fundamental and applied research across various scientific fields, from geology to physics, chemistry, cell biology, and particle toxicology. The pathogenic activity of silica is variable, depending on the physico-chemical features of the particles. In the last 50 years, crystallinity and capacity to generate free radicals have been recognized as relevant features for silica toxicity. The 'surface' also plays an important role in silica toxicity, but this term has often been used in a very general way, without defining which properties of the surface are actually driving toxicity. How the chemical features (e.g., silanols and siloxanes) and configuration of the silica surface can trigger toxic responses remains incompletely understood. MAIN BODY: Recent developments in surface chemistry, cell biology and toxicology provide new avenues to improve our understanding of the molecular mechanisms of the adverse responses to silica particles. New physico-chemical methods can finely characterize and quantify silanols at the surface of silica particles. Advanced computational modelling and atomic force microscopy offer unique opportunities to explore the intimate interactions between silica surface and membrane models or cells. In recent years, interdisciplinary research, using these tools, has built increasing evidence that surface silanols are critical determinants of the interaction between silica particles and biomolecules, membranes, cell systems, or animal models. It also has become clear that silanol configuration, and eventually biological responses, can be affected by impurities within the crystal structure, or coatings covering the particle surface. The discovery of new molecular targets of crystalline as well as amorphous silica particles in the immune system and in epithelial lung cells represents new possible toxicity pathways. Cellular recognition systems that detect specific features of the surfa |
| مصطلحات الفهرس: | Atomic force microscopy, Auto-immune diseases, Coating, Lung cancer, Modelling, Silanol, Silica, Silicosis, Spectroscopy, Surface reactivity, info:eu-repo/semantics/article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| Other Numbers: | UCDLC oai:dial.uclouvain.be:boreal:226909 boreal:226909 info:doi/10.1186/s12989-019-0315-3 info:pmid/31419990 urn:EISSN:1743-8977 1328229928 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1328229928 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |