Electronic Resource
How to fix DNA-protein crosslinks
| العنوان: | How to fix DNA-protein crosslinks |
|---|---|
| المؤلفون: | Kühbacher, Ulrike, Duxin, Julien P |
| المصدر: | Kühbacher , U & Duxin , J P 2020 , ' How to fix DNA-protein crosslinks ' , DNA Repair , vol. 94 , 102924 . |
| بيانات النشر: | 2020 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Proteins that act on DNA, or are in close proximity to it, can become inadvertently crosslinked to DNA and form highly toxic lesions, known as DNA-protein crosslinks (DPCs). DPCs are generated by different chemotherapeutics, environmental or endogenous sources of crosslinking agents, or by lesions on DNA that stall the catalytic cycle of certain DNA processing enzymes. These bulky adducts impair processes on DNA such as DNA replication or transcription, and therefore pose a serious threat to genome integrity. The large diversity of DPCs suggests that there is more than one canonical mechanism to repair them. Indeed, many different enzymes have been shown to act on DPCs by either processing the protein, the DNA or the crosslink itself. In addition, the cell cycle stage or cell type are likely to dictate pathway choice. In recent years, a detailed understanding of DPC repair during S phase has started to emerge. Here, we review the current knowledge on the mechanisms of replication-coupled DPC repair, and describe and also speculate on possible pathways that remove DPCs outside of S phase. Moreover, we highlight a recent paradigm shifting finding that indicates that DPCs are not always detrimental, but can also play a protective role, preserving the genome from more deleterious forms of DNA damage. |
| مصطلحات الفهرس: | article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf English |
| Other Numbers: | DAV oai:pure.atira.dk:publications/8cfa2431-583c-4a28-80bb-75f99b3ab6ee 1322746178 |
| المصدر المساهم: | UNIV OF COPENHAGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1322746178 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |