Electronic Resource
WIKI4, a Novel Inhibitor of Tankyrase and Wnt/beta-Catenin Signaling
| العنوان: | WIKI4, a Novel Inhibitor of Tankyrase and Wnt/beta-Catenin Signaling |
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| المؤلفون: | Morrisey, E, James, RG, Davidson, KC, Bosch, KA, Biechele, TL, Robin, NC, Taylor, RJ, Major, MB, Camp, ND, Fowler, K, Martins, TJ, Moon, RT |
| بيانات النشر: | PUBLIC LIBRARY SCIENCE 2012-12-05 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high throughput screening we have identified a new small molecule inhibitor of Wnt/ß-catenin signaling, WIKI4. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in human embryonic stem cells. Furthermore, we demonstrate that WIKI4 mediates its effects on Wnt/ß-catenin signaling by inhibiting the enzymatic activity of TNKS2, a regulator of AXIN ubiquitylation and degradation. While TNKS has previously been shown to be the target of small molecule inhibitors of Wnt/ß-catenin signaling, WIKI4 is structurally distinct from previously identified TNKS inhibitors. |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الاتاحة: | Open access content. Open access content CC BY https://creativecommons.org/licenses/by/4.0 |
| Other Numbers: | UMV oai:jupiter.its.unimelb.edu.au:11343/265241 James, R. G., Davidson, K. C., Bosch, K. A., Biechele, T. L., Robin, N. C., Taylor, R. J., Major, M. B., Camp, N. D., Fowler, K., Martins, T. J. & Moon, R. T. (2012). WIKI4, a Novel Inhibitor of Tankyrase and Wnt/beta-Catenin Signaling. PLOS ONE, 7 (12), https://doi.org/10.1371/journal.pone.0050457. 10.1371/journal.pone.0050457 1932-6203 1932-6203 1315730912 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1315730912 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |