Electronic Resource
The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
| العنوان: | The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis |
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| المؤلفون: | Bishai, W, Caws, M, Thwaites, G, Dunstan, S, Hawn, TR, Lan, NTN, Thuong, NTT, Stepniewska, K, Huyen, MNT, Bang, ND, Loc, TH, Gagneux, S, van Soolingen, D, Kremer, K, van der Sande, M, Small, P, Anh, PTH, Chinh, NT, Quy, HT, Duyen, NTH, Tho, DQ, Hieu, NT, Torok, E, Hien, TT, Dung, NH, Nhu, NTQ, Duy, PM, Chau, NVV, Farrar, J |
| بيانات النشر: | PUBLIC LIBRARY SCIENCE 2008-03 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsible for the innate immune response to infection. We compared the host and bacterial genotype in 187 Vietnamese adults with tuberculous meningitis (TBM) and 237 Vietnamese adults with uncomplicated pulmonary tuberculosis. The host genotype of tuberculosis cases was also compared with the genotype of 392 cord blood controls from the same population. Isolates of M. tuberculosis were genotyped by large sequence polymorphisms. The hosts were defined by polymorphisms in genes encoding Toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and Toll-like receptor-2 (TLR-2). We found a significant protective association between the Euro-American lineage of M. tuberculosis and pulmonary rather than meningeal tuberculosis (Odds ratio (OR) for causing TBM 0.395, 95% confidence intervals (C.I.) 0.193-0.806, P = 0.009), suggesting these strains are less capable of extra-pulmonary dissemination than others in the study population. We also found that individuals with the C allele of TLR-2 T597C allele were more likely to have tuberculosis caused by the East-Asian/Beijing genotype (OR = 1.57 [95% C.I. 1.15-2.15]) than other individuals. The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis. |
| مصطلحات الفهرس: | Journal Article |
| URL: | |
| الاتاحة: | Open access content. Open access content CC BY https://creativecommons.org/licenses/by/4.0 |
| Other Numbers: | UMV oai:jupiter.its.unimelb.edu.au:11343/261623 Caws, M., Thwaites, G., Dunstan, S., Hawn, T. R., Lan, N. T. N., Thuong, N. T. T., Stepniewska, K., Huyen, M. N. T., Bang, N. D., Loc, T. H., Gagneux, S., van Soolingen, D., Kremer, K., van der Sande, M., Small, P., Anh, P. T. H., Chinh, N. T., Quy, H. T., Duyen, N. T. H. ,... Farrar, J. (2008). The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLOS PATHOGENS, 4 (3), https://doi.org/10.1371/journal.ppat.1000034. 10.1371/journal.ppat.1000034 1553-7374 1553-7366 1315667859 |
| المصدر المساهم: | UNIV OF MELBOURNE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1315667859 |
| قاعدة البيانات: | OAIster |
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