Electronic Resource
Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation
| العنوان: | Multicenter evaluation of parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation |
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| المؤلفون: | Cheng, Guang‐Shing, Selwa, Katherine E., Hatt, Charles, Ram, Sundaresh, Fortuna, Aleksa B., Guerriero, Margaret, Himelhoch, Ben, McAree, Daniel, Hoffman, Timothy C., Brisson, Joseph, Nazareno, Ryan, Bloye, Kiernan, Johnson, Timothy D., Remberger, Mats, Mattsson, Jonas, Vummidi, Dharshan, Kazerooni, Ella E., Lama, Vibha N., Galban, Stefanie, Boeckh, Michael, Yanik, Gregory A., Galban, Craig J. |
| بيانات النشر: | Uppsala universitet, Hematologi Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington University of Michigan Medical School Ann Arbor Michigan Imbio, LLC Minneapolis Minneapolis Minnesota Department of Radiology Michigan Medicine Ann Arbor Michigan Department of Radiology Michigan Medicine Ann Arbor Michigan Seattle Cancer Care Alliance Seattle Washington Michigan State University College of Human Medicine Lansing Michigan Pediatrics University of Michigan Ann Arbor Michigan University of Michigan Medical School Ann Arbor Michigan Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan Department of Biostatistics University of Michigan School of Public Health Ann Arbor Michigan Department of Oncology‐Pathology Karolinska University Hospital Stockholm Sweden Department of Oncology‐Pathology Karolinska University Hospital Stockholm Sweden Department of Radiology Michigan Medicine Ann Arbor Michigan Department of Radiology Michigan Medicine Ann Arbor Michigan Division of Pulmonary and Critical Care Medicine Michigan Medicine Ann Arbor Michigan Department of Radiology Michigan Medicine Ann Arbor Michigan Clinical Research Division Fred Hutchinson Cancer Research Center Seattle Washington Blood and Marrow Transplant Program Michigan Medicine Ann Arbor Michigan Department of Radiology Michigan Medicine Ann Arbor Michigan Wiley 2020 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Parametric response mapping (PRM) is a novel computed tomography (CT) technology that has shown potential for assessment of bronchiolitis obliterans syndrome (BOS) after hematopoietic stem cell transplantation (HCT). The primary aim of this study was to evaluate whether variations in image acquisition under real-world conditions affect the PRM measurements of clinically diagnosed BOS. CT scans were obtained retrospectively from 72 HCT recipients with BOS and graft-versus-host disease from Fred Hutchinson Cancer Research Center, Karolinska Institute, and the University of Michigan. Whole lung volumetric scans were performed at inspiration and expiration using site-specific acquisition and reconstruction protocols. PRM and pulmonary function measurements were assessed. Patients with moderately severe BOS at diagnosis (median forced expiratory volume at 1 second [FEV1] 53.5% predicted) had similar characteristics between sites. Variations in site-specific CT acquisition protocols had a negligible effect on the PRM-derived small airways disease (SAD), that is, BOS measurements. PRM-derived SAD was found to correlate with FEV1% predicted and FEV1/ forced vital capacity (R = −0.236, P = .046; and R = −0.689, P < .0001, respectively), which suggests that elevated levels in the PRM measurements are primarily affected by BOS airflow obstruction and not CT scan acquisition parameters. Based on these results, PRM may be applied broadly for post-HCT diagnosis and monitoring of BOS. |
| مصطلحات الفهرس: | Clinical Medicine, Klinisk medicin, Hematology, Hematologi, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1111.ajt.15814 |
| URL: | American Journal of Transplantation, 1600-6135, 2020, 20:8, s. 2198-2205 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| Other Numbers: | UPE oai:DiVA.org:uu-463320 0000-0003-0520-4312 0000-0001-5596-7487 doi:10.1111/ajt.15814 PMID 32034974 ISI:000554024900027 1312840487 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1312840487 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1111.ajt.15814 |
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