Electronic Resource
The proteomic landscape of renal tumors
| العنوان: | The proteomic landscape of renal tumors |
|---|---|
| المؤلفون: | Chinello, C, L'Imperio, V, Stella, M, Smith, A, Bovo, G, Grasso, A, Grasso, M, Raimondo, F, Pitto, M, Pagni, F, Magni, F, CHINELLO, CLIZIA, STELLA, MARTINA, SMITH, ANDREW JAMES, RAIMONDO, FRANCESCA, PITTO, MARINA, PAGNI, FABIO, MAGNI, FULVIO |
| بيانات النشر: | Taylor and Francis Ltd country:GB 2016 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Introduction: Renal cell carcinoma (RCC) is the most fatal of the common urologic cancers, with approximately 35% of patients dying within 5 years following diagnosis. Therefore, there is a need for non-invasive markers that are capable of detecting and determining the severity of small renal masses at an early stage in order to tailor treatment and follow-up. Proteomic studies have proved to be very useful in the study of tumors. Areas covered: In this review, we will detail the current knowledge obtained by the different proteomic approaches, focusing on MS-based strategies, used to investigate RCC biology in order to identify diagnostic, prognostic and predictive biomarkers on tissue, cultured cells and biological fluids. Expert commentary: Currently, no reliable biomarkers or targets for RCC have been translated into the clinical setting. Moreover, despite the efforts of proteomics and other-omics disciplines, only a small number of them have been observed as shared targets between the different analytical platforms and biological specimens. The difficulty to define a specific molecular pattern for RCC and its subtypes highlights a peculiar profile and a heterogeneity that must be taken into account in future studies. |
| مصطلحات الفهرس: | Biological fluid, Biomarker, Cancer, Kidney, Mass spectrometry imaging, Peptidome, Proteome, Proteomic, Renal cell carcinoma, Tissue, biological fluid, biomarker, cancer, kidney, mass spectrometry imaging, peptidome, proteome, proteomic, tissue, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/27748142 info:eu-repo/semantics/altIdentifier/wos/WOS:000389035200006 volume:13 issue:12 firstpage:1103 lastpage:1120 numberofpages:18 journal:EXPERT REVIEW OF PROTEOMICS |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | ITBAO oai:boa.unimib.it:10281/133795 10.1080/14789450.2016.1248415 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84996593727 1308918685 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1308918685 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |