Electronic Resource
Ghrelin inhibits inflammatory pain in rats: Involvement of the opioid system
| العنوان: | Ghrelin inhibits inflammatory pain in rats: Involvement of the opioid system |
|---|---|
| المؤلفون: | Sibilia, V, Lattuada, N, Rapetti, D, Pagani, F, Vincenza, D, Bulgarelli, I, Locatelli, V, Guidobono, F, Netti, C, Netti, C., LOCATELLI, VITTORIO |
| بيانات النشر: | PERGAMON-ELSEVIER SCIENCE LTD country:xxk 2006-09 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | This study examined the effects of intracerebroventricular (i.c.v.), intraperitoneal (i.p.) or intraplantar (i.pl.) administration of ghrelin, the endogenous ligand of the growth hormone secretagogue receptor, in the development of hyperalgesia and edema induced by intraplantar injection of carrageenan in rats. Central ghrelin (4 ng to 4 microg/rat) given 5 min before carrageenan produced a dose-related reversal of carrageenan-induced mechanical hyperalgesia measured by Randall-Selitto test with an ED50 of 81.7 ng/rat. Ghrelin at the dose of 4 microg/rat i.c.v. was also effective in inhibiting edema. When ghrelin (4 microg/rat i.c.v.) was administered 150 min after carrageenan, it failed to modify either hyperalgesia or the paw volume. Given i.p., 30 min before carrageenan, ghrelin (20-160 microg/kg) induced a significant dose-dependent inhibition of hyperalgesia with an ED50 of 77 microg/kg and a slight reduction of edema. Intraplantar ghrelin (40 ng to 12 microg/rat) did not significantly modify both the hyperalgesic and edematous activities of carrageenan. The anti-hyperalgesic and anti-edematous effects of ghrelin (4 microg/rat i.c.v.) were reversed by naloxone (10 microg/rat i.c.v.). Systemic administration of the peripheral selective opioid antagonist, naloxone methiodide (3 mg/kg s.c.), did not antagonize antinociception elicited by i.p. ghrelin. Overall these data indicate that ghrelin exerts an inhibitory role on inflammatory pain through an interaction with the central opioid system. |
| مصطلحات الفهرس: | Ghrelin, Hyperalgesia, Randall-Selitto, Edema, Opioid system, BIO/14 - FARMACOLOGIA, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/16759671 info:eu-repo/semantics/altIdentifier/wos/WOS:000240811900010 volume:51 issue:3 firstpage:497 lastpage:505 journal:NEUROPHARMACOLOGY |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | ITBAO oai:boa.unimib.it:10281/1979 10.1016/j.neuropharm.2006.04.009 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33747083179 1308891511 |
| المصدر المساهم: | BICOCCA OPEN ARCH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1308891511 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |