Electronic Resource
A clinical trial of the effects of estrogen in acutely psychotic women.
| العنوان: | A clinical trial of the effects of estrogen in acutely psychotic women. |
|---|---|
| المؤلفون: | Copolov D., Kulkarni J., De Castella A., Smith D., Taffe J., Keks N. |
| بيانات النشر: | Elsevier (P.O. Box 211, Amsterdam 1000 AE, Netherlands) Netherlands 2012-10-22 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | This study was a preliminary open clinical trial aimed at exploring the hypothesis that estrogen may provide protection against schizophrenia in women. Eleven women with acute psychotic symptoms, as scored on the BPRS, SAPS and SANS, had 0.02 mg estradiol added to neuroleptic treatment for eight weeks. Their response was compared to seven women with similar symptom severity receiving neuroleptic treatment alone. Both groups had baseline hormonal assays of estrogen, progesterone, LH and FSH and underwent regular psychopathology ratings during the eight weeks. The group receiving the estradiol adjunct showed more rapid improvement in psychotic symptoms compared with the group receiving neuroleptics only. This difference was not sustained for the entirety of the trial. Both groups reached similar levels of recovery by the eighth week. These results suggest that estradiol may have antipsychotic properties and/or act as a catalyst for neuroleptic responsiveness in women with schizophrenia. |
| مصطلحات الفهرس: | clinical article, clinical trial, controlled clinical trial, controlled study, female, human, schizophrenia/dt [Drug Therapy], benzodiazepine/dt [Drug Therapy], chlorpromazine/dt [Drug Therapy], estradiol/ct [Clinical Trial], estradiol/dt [Drug Therapy], estrogen/ct [Clinical Trial], estrogen/dt [Drug Therapy], haloperidol/dt [Drug Therapy], neuroleptic agent/dt [Drug Therapy], thioridazine/dt [Drug Therapy], trifluoperazine/dt [Drug Therapy], priority journal, adult, article, Article |
| URL: | Click here for full text options LibKey Link |
| الاتاحة: | Open access content. Open access content Copyright 2012 Elsevier B.V., All rights reserved. |
| Other Numbers: | AUSHL oai:repository.monashhealth.org:1/33981 Schizophrenia Research. 20 (3) (pp 247-252), 1996. Date of Publication: 05 Jul 1996. 0920-9964 https://repository.monashhealth.org/monashhealthjspui/handle/1/33981 8827850 [http://www.ncbi.nlm.nih.gov/pubmed/?term=8827850] 26232968 (Kulkarni, De Castella, Smith, Taffe, Keks, Copolov) Monash Univ. Dept. of Psychol. Med., Dandenong Hospital, Dandenong, Vic., Australia 1305136004 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305136004 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |