Electronic Resource
IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis.
| العنوان: | IL-12 directs severe renal injury, crescent formation and Th1 responses in murine glomerulonephritis. |
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| المؤلفون: | Kitching A.R., Holdsworth S.R., Tipping P.G. |
| بيانات النشر: | Wiley-VCH Verlag (P.O. Box 101161, Weinheim D-69451, Germany) Germany 2012-10-19 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Glomerular crescent formation characterizes severe glomerulonephritis (GN). Evidence suggests that crescent formation results from a delayed-type hypersensitivity-like Th1 response. As IL-12 directs Th1 responses, we tested the hypothesis that IL-12 is important in crescentic GN. Neutralization of IL-12 attenuated crescent formation and cell-mediated injury in C57BL/6 mice sensitized to and challenged with sheep anti-mouse glomerular basement membrane (GBM) globulin. Recombinant IL-12 induced severe crescentic GN with enhanced Th1 responses in C57BL/6 mice in which non-crescentic GN was induced by injecting anti-GBM globulin into naive mice. BALB/c mice do not develop significant crescent formation in these models, due either to regulatory effects of IL-4, or to deficits in IL-12 production/responsiveness. Administering IL-12 to BALB/c mice with GN induced Th1 responses and crescent formation, whereas IL-4-deficient BALB/c mice did not develop cell-mediated crescentic injury when GN was induced in sensitized mice. These results establish a central role for IL-12 in severe crescentic GN. |
| مصطلحات الفهرس: | controlled study, glomerulonephritis, helper cell, kidney injury/et [Etiology], male, mouse, nonhuman, priority journal, glomerulus basement membrane antibody, interleukin 12/ec [Endogenous Compound], interleukin 4/ec [Endogenous Compound], recombinant interleukin 12, article, animal experiment, Article |
| URL: | Click here for full text options LibKey Link |
| الاتاحة: | Open access content. Open access content Copyright 2012 Elsevier B.V., All rights reserved. |
| Other Numbers: | AUSHL oai:repository.monashhealth.org:1/33571 European Journal of Immunology. 29 (1) (pp 1-10), 1999. Date of Publication: 1999. 0014-2980 https://repository.monashhealth.org/monashhealthjspui/handle/1/33571 9933080 [http://www.ncbi.nlm.nih.gov/pubmed/?term=9933080] 29043516 (Kitching, Tipping, Holdsworth) Centre for Inflammatory Diseases, Monash University, Monash Medical Centre, Clayton, Vic., Australia (Kitching) Department of Medicine, Monash Medical Centre, Monash University, 246 Clayton Road, Clayton, Vic. 3168, Australia Kitching A.R.; richard.kitching@med.monash.edu.au 1305135774 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305135774 |
| قاعدة البيانات: | OAIster |
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