Electronic Resource
Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: A prospective observational cohort study.
| العنوان: | Urinary interleukin-18 does not predict acute kidney injury after adult cardiac surgery: A prospective observational cohort study. |
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| المؤلفون: | Haase-Fielitz A., Haase M., Bellomo R., Story D., Davenport P. |
| بيانات النشر: | BioMed Central Ltd. (34 - 42 Cleveland Street, London W1T 4LB, United Kingdom) United Kingdom 2008-09-08 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Introduction: Urinary interleukin-18 (IL-18) measured during the immediate postoperative period could be a promising predictor of acute kidney injury following adult cardiac surgery. Method(s): In a single-centre prospective observational cohort study, we enrolled 100 adult cardiac surgical patients undergoing cardiopulmonary bypass at a tertiary hospital. We measured the urinary concentration of IL-18 and creatinine preoperatively, on arrival in the intensive care unit, and 24 hours postoperatively. We assessed urinary IL-18 concentration and urinary IL-18/urinary creatinine ratio in relation to the postoperative development of acute kidney injury defined as an increase in serum creatinine of greater than 50% from preoperative to postoperative peak value within 48 hours after surgery. Result(s): Twenty patients developed acute kidney injury. On arrival in the intensive care unit and at 24 hours postoperatively, urinary IL-18 (median [interquartile range]) was not different in patients who subsequently developed acute kidney injury compared with those who did not: on arrival in the intensive care unit (168 [717] versus 104 [256] pg/mL; P = 0.70) and at 24 hours (195 [483] versus 165 [246] pg/mL; P = 0.47). On arrival in the intensive care unit (area under the curve for the receiver operating characteristic curve [AUC-ROCC] 0.53, 95% confidence interval [CI] 0.38 to 0.68; P = 0.70) and at 24 hours postoperatively (AUC-ROCC 0.55, 95% CI 0.40 to 0.71; P = 0.48), urinary IL-18 was not better than chance in predicting acute kidney injury. All findings were confirmed when urinary IL-18 was adjusted for urinary creatinine. Urinary IL-18 correlated with duration of cardiopulmonary bypass (P < 0.001). Conclusion(s): In adults, early postoperative measurement of urinary IL-18 appears not to be valuable in identifying patients who develop acute kidney injury after cardiac surgery, but rather represents a nonspecific marker of cardiopulmonary bypass-associated systemic inflamma |
| مصطلحات الفهرس: | interleukin 18/ec [Endogenous Compound], insulin/dt [Drug Therapy], furosemide, creatine/ec [Endogenous Compound], antidiabetic agent/dt [Drug Therapy], tertiary health care, protein urine level, prospective study, priority journal, prediction, adult, aged, article, cardiopulmonary bypass, cohort analysis, controlled study, creatinine blood level, creatinine urine level, diabetes mellitus/dt [Drug Therapy], female, heart surgery, human, inflammation, intensive care unit, kidney injury, major clinical study, male, postoperative period, observational study, Article |
| URL: | Click here for full text options LibKey Link |
| الاتاحة: | Open access content. Open access content Copyright 2012 Elsevier B.V., All rights reserved. |
| Other Numbers: | AUSHL oai:repository.monashhealth.org:1/31452 Critical Care. 12 (4) (no pagination), 2008. Article Number: R96. Date of Publication: 01 Aug 2008. 1364-8535 https://repository.monashhealth.org/monashhealthjspui/handle/1/31452 18673539 [http://www.ncbi.nlm.nih.gov/pubmed/?term=18673539] 352203714 (Haase, Bellomo, Haase-Fielitz) Department of Intensive Care, Austin Health, Melbourne, 145 Studley Rd, Heidelberg, VIC 3084, Australia (Haase, Haase-Fielitz) Department of Nephrology and Intensive Care Medicine, Charite University Medicine, 1 Augustenburger Platz, Berlin 13353, Germany (Story) Department of Anaesthesiology, Austin Health, Melbourne, 145 Studley Rd, Heidelberg, VIC 3084, Australia (Davenport) Department of Medicine, Monash Medical Centre, 168 Clayton Rd, Clayton, VIC 3168, Australia Bellomo R.; rinaldo.bellomo@med.monash.edu.au Haase M.; michael.haase@charite.de Haase-Fielitz A.; anja.haase-fielitz@austin.org.au Story D.; david.story@austin.org.au Davenport P.; piersdavenport@hotmail.com 1305132649 |
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| رقم الانضمام: | edsoai.on1305132649 |
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