Electronic Resource
Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment.
| العنوان: | Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment. |
|---|---|
| المؤلفون: | Nguyen T.V., Palmer K.R., Tong S., Kaitu'u-Lino T.J., Hannan N.J., Brownfoot F.C., Cannon P., Deo M., Beard S. |
| بيانات النشر: | NLM (Medline) United Kingdom 2018-11-17 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Preeclampsia is a disease of pregnancy associated with placental oxidative stress, inflammation and elevated release of anti-angiogenic factors sFlt-1 and soluble endoglin. These placental factors cause generalized maternal endothelial dysfunction. There are no treatments to halt disease progression; delivery is the only cure. Resveratrol modulates pathways involved in inflammation and oxidative stress and may offer a potential therapeutic for preeclampsia. Resveratrol reduced sFlt-1, sFlt-1 e15a and soluble endoglin secretion from primary trophoblasts and HUVECs and reduced mRNA expression of pro-inflammatory molecules NFkappaB, IL-6 and IL-1beta in trophoblasts. IL-6, IL-1beta and TNFalpha secretion were also significantly reduced. In HUVECs, resveratrol significantly increased mRNA of anti-oxidant enzymes HO-1, NQO1, GCLC and TXN but did not significantly alter HO-1 protein expression, whilst reducing HO-1 protein in trophoblast. Endothelial dysfunction was induced in HUVECs using TNFalpha, increasing expression of cell adhesion molecule VCAM1 and adhesion of peripheral blood mononuclear cells, both of which were increased further by resveratrol. In contrast, resveratrol significantly reduced TNFalpha-induced Endothelin-1 (a vasoconstrictor) and significantly increased the phosphorylation of endothelial nitric oxide synthase (eNOS). In summary, resveratrol decreases secretion of anti-angiogenic factors however its effects on the endothelium are mixed. Overall, it may have potential as a treatment for preeclampsia. |
| مصطلحات الفهرس: | heme oxygenase 1, resveratrol/pd [Pharmacology], resveratrol/dt [Drug Therapy], vasculotropin receptor 1, antagonists and inhibitors, FLT1 protein, human, preeclampsia/et [Etiology], biosynthesis, blood vessel, cell survival, drug effect, female, genetics, human, metabolism, oxidative stress, preeclampsia/dt [Drug Therapy], pregnancy, trophoblast, umbilical vein endothelial cell, vascular endothelium, antioxidant/pd [Pharmacology], autacoid, biological marker, cytokine, endoglin, endothelial nitric oxide synthase, Article |
| URL: | Click here for full text options LibKey Link |
| الاتاحة: | Open access content. Open access content This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine |
| Other Numbers: | AUSHL oai:repository.monashhealth.org:1/38594 Scientific reports. 7 (1) (pp 1819), 2017. Date of Publication: 12 May 2017. 2045-2322 (electronic) https://repository.monashhealth.org/monashhealthjspui/handle/1/38594 28500309 [http://www.ncbi.nlm.nih.gov/pubmed/?term=28500309] 624929042 (Hannan, Brownfoot, Cannon, Deo, Beard, Nguyen, Tong) Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Rd, Heidelberg, 3084, Victoria, Australia (Palmer) Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, 246 Clayton Rd ,Clayton, Victoria 3168, Australia (Kaitu'u-Lino) Translational Obstetrics Group, The Department of Obstetrics and Gynaecology, Mercy Hospital for Women, University of Melbourne, 163 Studley Rd, Heidelberg, 3084, Victoria, Australia. t.klino@unimelb.edu.au 1305125909 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305125909 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |