Electronic Resource
Karyomegalic nephropathy: An uncommon cause of progressive renal failure.
| العنوان: | Karyomegalic nephropathy: An uncommon cause of progressive renal failure. |
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| المؤلفون: | Kerr P., Collett P., Cooke B.E., Newland R., Dowling J., Horvath J., Kalowski S., Bhandari S. |
| بيانات النشر: | Oxford University Press Oxford University Press (Great Clarendon Street, Oxford OX2 6DP, United Kingdom) United Kingdom 2002-11-19 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background. Karyomegalic nephropathy, first identified in 1974, represents an increasingly recognized, but perhaps underdiagnosed condition associated with interstitial nephritis. It undoubtedly leads to end-stage renal disease requiring renal support. Methods and results. We present a series of six cases of karyomegalic nephropathy. The age at diagnosis was 9-51 years, median 33 years. Impaired renal function, proteinuria, and haematuria were present in the majority of cases. Non-specific elevated liver enzymes were present in three cases. Two patients died, soon after transplantation from overwhelming respiratory sepsis. The classical histological features of large, abnormal hyperchromatic nuclei with irregular outlines within epithelial cells were present in renal epithelial cells. Abnormality of DNA ploidy distributions compared with age- and sex-matched controls, and characterized by the presence of significant numbers of cells with high ploidy values was present in cases but not in controls. Mitotic figures were absent. Proliferation markers, Ki-67 and proliferating cell nuclear antigen/cyclin were not significantly elevated in those cases examined. Human leukocyte antigen analysis did not support the clustering of A9 or B35, in the cases or their families. Conclusions. The presence of significant renal impairment, positive urine sediment, abnormal liver enzymes, and early age of onset should alert one to the presence of karyomegalic nephropathy. It represents an under-diagnosed disorder with a high degree of ploidy indicative of karyotypic abnormality. |
| مصطلحات الفهرس: | kidney function, lung infection/co [Complication], male, mitosis, ploidy, priority journal, proteinuria, school child, sepsis/co [Complication], cell antigen/ec [Endogenous Compound], cycline/ec [Endogenous Compound], cyclosporin/ae [Adverse Drug Reaction], cyclosporin/dt [Drug Therapy], Ki 67 antigen/ec [Endogenous Compound], leukocyte antigen/ec [Endogenous Compound], liver enzyme/ec [Endogenous Compound], kidney transplantation, adult, article, cause of death, clinical article, clinical feature, diagnostic procedure, disease course, epithelium cell, female, glomerulonephritis/di [Diagnosis], hematuria, hemolytic uremic syndrome/si [Side Effect], histology, human, karyotyping, kidney biopsy, kidney disease/di [Diagnosis], kidney epithelium, kidney failure/co [Complication], kidney failure/dt [Drug Therapy], kidney failure/su [Surgery], Article |
| URL: | Nephrology Dialysis Transplantation LibKey Link |
| الاتاحة: | Open access content. Open access content Copyright 2012 Elsevier B.V., All rights reserved. Copyright 2021 Elsevier B.V., All rights reserved. |
| Other Numbers: | AUSHL oai:repository.monashhealth.org:1/27238 Nephrology Dialysis Transplantation. 17 (11) (pp 1914-1920), 2002. Date of Publication: 01 Nov 2002. 0931-0509 https://repository.monashhealth.org/monashhealthjspui/handle/1/27238 12401846 [http://www.ncbi.nlm.nih.gov/pubmed/?term=12401846] 35277087 (Bhandari, Kalowski, Collett, Horvath) Statewide Renal Services, Royal Prince Alfred and Concord Repatriation Hospitals, Australia (Newland) Department of Anatomical Pathology, Royal Prince Alfred and Concord Repatriation Hospitals, Canada (Cooke) Department Anatomical Pathology, Prince of Wales Hospital, Sydney, NSW, Australia (Kerr) Department of Pathology, Alfred Hospital, Australia (Dowling) Monash Medical Centre, Melbourne, Vic., Australia (Bhandari) Hull and East Yorkshire Hospitals NHS Trust, Department of Renal Medicine, Hull Royal Infirmary, East Yorkshire HU3 2JZ, United Kingdom Bhandari S.; sunil.bhandari@medix-uk.com 1305125671 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305125671 |
| قاعدة البيانات: | OAIster |
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