Electronic Resource
Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial.
| العنوان: | Tranexamic acid in coronary artery surgery: One-year results of the Aspirin and Tranexamic Acid for Coronary Artery Surgery (ATACAS) trial. |
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| المؤلفون: | Krum H., Marianello D., Alvaro G., De Vuono G., van Dijk D., Dieleman J., Numan S., Parke R., Raudkivi P., Gilder E., Dunning J., Termaat J., Mans G., Alderton J., Waugh D., Platt M.J., Pai A., Sevillano A., Lal A., Sinclair C., Kunst G., Knighton A., Cubas G.M., Saravanan P., Myles P.S., Smith J.A., Kasza J., Silbert B., Jayarajah M., Painter T., Cooper D.J., Marasco S., McNeil J., Bussieres J.S., McGuinness S., Byrne K., Chan M.T.V., Landoni G., Wallace S., Forbes A., Esmore D., Tonkin A., Buxton B., Heritier S., Merry A., Liew D., Meehan A., Galagher W., Farrington C., Ditoro A., Wutzlhofer L., Story D., Peyton P., Baulch S., Sidiropoulos S., Potgieter D., Baker R.A., Pesudovs B., O'Loughlin J Wells E., Coutts P., Bolsin S., Osborne C., Ives K., Hulley A., Christie-Taylor G., Lang S., Mackay H., Cokis C., March S., Bannon P.G., Wong C., Turner L., Scott D., Said S., Corcoran P., de Prinse L., Gagne N., Lamy A., Semelhago L., Underwood M., Choi G.S.Y., Fung B., Lembo R., Monaco F., Simeone F., Millner R., Vasudevan V., Patteril M., Lopez E., Basu R., Lu J. |
| بيانات النشر: | Mosby Inc. (E-mail: customerservice@mosby.com) United States 2019-01-28 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Tranexamic acid reduces blood loss and transfusion requirements in cardiac surgery but may increase the risk of coronary graft thrombosis. We previously reported the 30-day results of a trial evaluating tranexamic acid for coronary artery surgery. Here we report the 1-year clinical outcomes. Method(s): Using a factorial design, we randomly assigned patients undergoing coronary artery surgery to receive aspirin or placebo and tranexamic acid or placebo. The results of the tranexamic acid comparison are reported here. The primary 1-year outcome was death or severe disability, the latter defined as living with a modified Katz activities of daily living score of less than 8. Secondary outcomes included a composite of myocardial infarction, stroke, and death from any cause through to 1 year after surgery. Result(s): The rate of death or disability at 1 year was 3.8% in the tranexamic acid group and 4.4% in the placebo group (relative risk, 0.85; 95% confidence interval, 0.64-1.13; P =.27), and this did not significantly differ according to aspirin exposure at the time of surgery (interaction P =.073). The composite rate of myocardial infarction, stroke, and death up to 1 year after surgery was 14.3% in the tranexamic acid group and 16.4% in the placebo group (relative risk, 0.87; 95% CI, 0.76-1.00; P =.053). Conclusion(s): In this trial of patients having coronary artery surgery, tranexamic acid did not affect death or severe disability through to 1 year after surgery. Further work should be done to explore possible beneficial effects on late cardiovascular events.Copyright © 2018 The American Association for Thoracic Surgery |
| مصطلحات الفهرس: | disease association, disease severity, female, double blind procedure, aged, article, blood transfusion, cerebrovascular accident, clinical decision making, clinical outcome, comparative effectiveness, comparative study, computer assisted tomography, controlled study, coronary artery surgery, daily life activity, priority journal, randomized controlled trial, surgical patient, treatment duration, acetylsalicylic acid/ct [Clinical Trial], acetylsalicylic acid/cm [Drug Comparison], placebo, tranexamic acid/ct [Clinical Trial], tranexamic acid/cm [Drug Comparison], follow up, functional status, heart infarction, human, major clinical study, male, medical record, mortality rate, New York Heart Association class, outcome assessment, postoperative period, Article |
| URL: | Journal of Thoracic and Cardiovascular Surgery LibKey Link |
| الاتاحة: | Open access content. Open access content Copyright 2019 Elsevier B.V., All rights reserved. |
| Other Numbers: | AUSHL oai:repository.monashhealth.org:1/35776 Journal of Thoracic and Cardiovascular Surgery. 157 (2) (pp 644-652.e9), 2019. Date of Publication: 01 Feb 2019. 0022-5223 https://repository.monashhealth.org/monashhealthjspui/handle/1/35776 Cardiothoracic Surgery 30459103 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30459103] 2001290921 (Myles, Cooper, Marasco, Wallace) Department of Anaesthesia and Perioperative Medicine, Alfred Hospital, Melbourne, Australia (Myles, Smith, Kasza, Cooper, Marasco, McNeil, Wallace, Forbes) Department of Anaesthesia and Perioperative Medicine, Monash University, Melbourne, Australia (Smith) Department of Cardiothoracic Surgery, Monash Medical Centre, Clayton, Australia (Silbert) Department of Anaesthesia, St Vincent's Hospital, Fitzroy, Australia (Jayarajah) Department of Cardiothoracic Anaesthesia and Cardiac Critical Care, South West Cardiac Centre, Derriford Hospital, Plymouth, United Kingdom (Painter) Royal Adelaide Hospital and Discipline of Acute Care Medicine, University of Adelaide, Adelaide, Australia (Bussieres) Department of Anesthesiology, Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec City, Quebec, Canada (McGuinness) Department of Cardiothoracic & Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand (Byrne) Department of Anaesthesia, Waikato Hospital, New Zealand (Chan) Department of Anesthesiology and Intensive Care, The Chinese University of Hong Kong, Hong Kong (Landoni) Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy Myles P.S.; p.myles@alfred.org.au 1305119705 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305119705 |
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