Electronic Resource
Antimicrobial resistance in UK neonatal units: NeonIN infection surveillance network.
| العنوان: | Antimicrobial resistance in UK neonatal units: NeonIN infection surveillance network. |
|---|---|
| المؤلفون: | Greenough A., Heath P.T., Kennea N., Bedford Russell A., Cailes B., Kortsalioudaki C., Buttery J., Pattnayak S., Matthes J. |
| بيانات النشر: | BMJ Publishing Group (E-mail: subscriptions@bmjgroup.com) United Kingdom 2018-08-31 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Objective To define the susceptibilities of the common causative pathogens of neonatal sepsis in the UK. Design Retrospective analysis of the prospectively collected neonIN infection surveillance network data between 2005 and 2014. Setting 30 neonatal units in the UK. Patients Newborns admitted to participating neonatal units who return a positive blood, cerebrospinal fluid or urine culture and are treated with at least 5 days of appropriate antibiotics. Results 1568 isolates with recorded antimicrobial data were collected including 328 early-onset sepsis (EOS) isolates and 1240 late-onset sepsis (LOS) isolates. The majority of EOS pathogens (>92%) were susceptible to the four empirical commonly used antimicrobial combinations (eg, 93% for benzylpenicillin/gentamicin), while LOS pathogens demonstrated higher levels of resistance (eg, 89% for flucloxacillin/gentamicin). Among infants<1500 g and <32 weeks gestation, an amoxicillin/gentamicin combination demonstrated a trend towards improved coverage of EOS isolates than benzylpenicillin/gentamicin (93% vs 86%, p=0.211). Conclusions This analysis provides insights into the patterns of antimicrobial resistance among UK neonatal pathogens. These data will inform areas of future research and can be used to update national evidence-based guidelines on antimicrobial usage.Copyright © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. |
| مصطلحات الفهرس: | Pseudomonas, Serratia, Staphylococcus aureus, Streptococcus, Streptococcus agalactiae, treatment outcome, Escherichia coli, Enterococcus, Enterobacter, birth weight, antibiotic sensitivity, newborn sepsis/dr [Drug Resistance], nonhuman, practice guideline, priority journal, vancomycin/dt [Drug Therapy], antibiotic resistance, Acinetobacter, human, infectious agent, Klebsiella, Micrococcus, newborn, newborn sepsis/dt [Drug Therapy], article, United Kingdom, amoxicillin/cb [Drug Combination], amoxicillin/dt [Drug Therapy], antiinfective agent/dt [Drug Therapy], cefotaxime/cb [Drug Combination], cefotaxime/dt [Drug Therapy], clavulanic acid/cb [Drug Combination], clavulanic acid/dt [Drug Therapy], flucloxacillin/cb [Drug Combination], flucloxacillin/dt [Drug Therapy], gentamicin/cb [Drug Combination], gentamicin/dt [Drug Therapy], penicillin G/cb [Drug Combination], penicillin G/dt [Drug Therapy], piperacillin plus tazobactam/cb [Drug Combination], piperacillin plus tazobactam/dt [Drug Therapy], vancomycin/cb [Drug Combination], Article |
| URL: | Archives of Disease in Childhood: Fetal and Neonatal Edition Click here for full text options LibKey Link |
| الاتاحة: | Open access content. Open access content Copyright 2018 Elsevier B.V., All rights reserved. |
| Other Numbers: | AUSHL oai:repository.monashhealth.org:1/38596 Archives of Disease in Childhood: Fetal and Neonatal Edition. 103 (5) (pp F474-F478), 2018. Date of Publication: 01 Sep 2018. 1359-2998 https://repository.monashhealth.org/monashhealthjspui/handle/1/38596 29074716 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29074716] 622727024 (Cailes, Kortsalioudaki, Heath) Paediatric Infectious Diseases Research Group, St George's University of London, Cranmer Terrace, London SW11 0RU, United Kingdom (Buttery) Department of Infection and Immunity, Monash Children's, Monash Medical Centre, Clayton, Australia (Pattnayak) Oliver Fisher Neonatal Unit, Medway NHS Foundation Trust, Gillingham, United Kingdom (Greenough) Department of Women and Children's Health, Kings College London, Kings College Hospital, London, United Kingdom (Matthes) Singleton Hospital NICU, Singleton Hospital, Swansea, United Kingdom (Bedford Russell) Birmingham Women's Hospital NICU, Birmingham Women's NHS Foundation Trust, Birmingham, United Kingdom (Kennea) St George's University NHS Foundation Trust, London, United Kingdom Cailes B.; bcailes@sgul.ac.uk 1305111066 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305111066 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |