Electronic Resource
Hepatic ischemia reperfusion injury: Contemporary perspectives on pathogenic mechanisms and basis for hepatoprotection-the good, bad and deadly
| العنوان: | Hepatic ischemia reperfusion injury: Contemporary perspectives on pathogenic mechanisms and basis for hepatoprotection-the good, bad and deadly |
|---|---|
| المؤلفون: | Teoh, Narcissus |
| المصدر: | Journal of Gastroenterology and Hepatology |
| بيانات النشر: | Blackwell Publishing Ltd 2011 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Hepatic ischemia reperfusion (IR) injury is an important clinical problem complicating liver surgery and transplantation. The pathogenesis underlying reperfusion injury after warm ischemia is complex, encompassing a multitude of different cell types and signalling mechanisms innate and/or mobilized to the liver. Since the author's 2003 review in the Journal, considerable progress has been achieved in enhancing our understanding of some of the pathogenic pathways and crucial mediators of hepatic inflammation such as the heme oxygenase system, CXC chemokines, Toll-like receptors as well as the mode of parenchymal cell death in IR injury. A better appreciation of these mechanisms will accelerate efforts in designing optimal interventions to prevent hepatic IR injury and improve outcomes after liver transplantation. |
| مصطلحات الفهرس: | Keywords: chemokine receptor CXCR4; CXCL1 chemokine; CXCL2 chemokine; CXCL3 chemokine; ferritin; heme oxygenase; interleukin 12; reactive oxygen metabolite; toll like receptor; toll like receptor 1; toll like receptor 10; toll like receptor 2; toll like receptor 3; Chemokines; Heme oxygenase; Hepatocyte cell death; Inflammation; Kupffer cells; Liver ischemia reperfusion injury; Neutrophils; Receptor for Advanced Glycation End Products (RAGE); Toll-Like Receptor (TLR); Tumor necrosis factor-a, Journal article |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| Other Numbers: | AUANP oai:openresearch-repository.anu.edu.au:1885/65502 0815-9319 1291791941 |
| المصدر المساهم: | AUSTRALIAN NAT UNIV - PRINT REPOSITORY From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1291791941 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |