Electronic Resource
Rest-Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study.
| العنوان: | Rest-Activity Rhythms and Cognitive Decline in Older Men: The Osteoporotic Fractures in Men Sleep Study. |
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| المؤلفون: | Rogers-Soeder, Tara S, Rogers-Soeder, Tara S, Blackwell, Terri, Yaffe, Kristine, Ancoli-Israel, Sonia, Redline, Susan, Cauley, Jane A, Ensrud, Kristine E, Paudel, Misti, Barrett-Connor, Elizabeth, LeBlanc, Erin, Stone, Katie, Lane, Nancy E, Tranah, Greg, Osteoporotic Fractures in Men Study Research Group |
| المصدر: | Journal of the American Geriatrics Society; vol 66, iss 11, 2136-2143; 0002-8614 |
| بيانات النشر: | eScholarship, University of California 2018-11-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | OBJECTIVE:To examine rest-activity circadian rhythm (RAR) and cognitive decline in older men. DESIGN:Longitudinal. SETTING:Osteoporotic Fractures in Men (MrOS) and ancillary Outcomes of Sleep Disorders in Men (MrOS Sleep) studies. PARTICIPANTS:MrOS and MrOS Sleep participants (N=2,754; mean age 76.0 ± 5.3). MEASUREMENTS:The Modified Mini-Mental State examination (3MS) was used to assess cognition at baseline (2003-05) and follow-up examinations (2005-06 and 2007-09). Wrist actigraphy was used to measure 24-hour activity counts at baseline. RAR variables included amplitude (strength of activity rhythm), mesor (mean activity level), pseudo F-statistic (overall circadian rhythm robustness), and acrophase (time of daily peak activity). RESULTS:After an average of 3.4 ± 0.5 years, men with lower amplitudes, mesors, and pseudo F-statistics had greater decline in 3MS performance (amplitude: -0.7 points Q1 vs -0.5 points Q4, p<.001; mesor: -0.5 points Q1 vs -0.2 points Q4, p=.01; pseudo F-statistic: -0.5 points Q1 vs -0.3 points Q4, p<.001). Lower amplitudes and pseudo-F statistics were associated with greater odds of clinically significant cognitive decline (≥5-point decrease) (amplitude Q1 vs. Q4: odds ratio (OR)=1.4, 95% confidence interval (CI)=1.0-1.9; pseudo-F statistic Q1 vs Q4: OR=1.4, 95% CI=1.0-1.9). Men with phase-advanced acrophase had greater odds of clinically significant cognitive decline (OR=1.8, 95% CI=1.2-2.8). Results were adjusted for multiple confounders. CONCLUSION:Several parameters of disrupted RAR (lower amplitude, pseudo F-statistic, mesor, phase-advanced acrophase) were associated with greater cognitive decline in older community-dwelling men. These findings contribute to a growing body of evidence suggesting that altered RARs are associated with cognitive decline in older adults. J Am Geriatr Soc 66:2136-2143, 2018. |
| مصطلحات الفهرس: | Osteoporotic Fractures in Men Study Research Group, Humans, Polysomnography, Risk Factors, Longitudinal Studies, Circadian Rhythm, Rest, Aged, Male, Actigraphy, Independent Living, Sleep Wake Disorders, Cognitive Dysfunction, cognitive decline, men, rest-activity rhythm, Neurosciences, Clinical Research, Sleep Research, Aging, Medical And Health Sciences, Geriatrics, Medical and Health Sciences, article |
| URL: | |
| الاتاحة: | Open access content. Open access content public |
| ملاحظة: | Journal of the American Geriatrics Society vol 66, iss 11, 2136-2143 0002-8614 |
| Other Numbers: | CDLER oai:escholarship.org:ark:/13030/qt43q9r7w4 qt43q9r7w4 https://escholarship.org/uc/item/43q9r7w4 https://escholarship.org/ 1287329772 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1287329772 |
| قاعدة البيانات: | OAIster |
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