Electronic Resource
Whole genomic sequencing based genotyping reveals a specific X3 sublineage restricted to Mexico and related with multidrug resistance
| العنوان: | Whole genomic sequencing based genotyping reveals a specific X3 sublineage restricted to Mexico and related with multidrug resistance |
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| المؤلفون: | Universidad Veracruzana, Comas, Iñaki [0000-0001-5504-9408], Jiménez-Ruano, Ana Cristina, Madrazo-Moya, Carlos Francisco, Cancino-Muñoz, Irving, Mejía-Ponce, Paulina M., Licona-Cassani, Cuauhtémoc, Comas, Iñaki, Muñiz-Salazar, Raquel, Zenteno-Cuevas, Roberto |
| بيانات النشر: | Nature Publishing Group 2021-01-21 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Whole genome sequencing (WGS) has been shown to be superior to traditional procedures of genotyping in tuberculosis (TB), nevertheless, reports of its use in drug resistant TB (DR-TB) isolates circulating in Mexico, are practically unknown. Considering the above the main of this work was to identify and characterize the lineages and genomic transmission clusters present in 67 DR-TB isolates circulating in southeastern Mexico. The results show the presence of three major lineages: L1 (3%), L2 (3%) and L4 (94%), the last one included 16 sublineages. Sublineage 4.1.1.3 (X3) was predominant in 18 (27%) of the isolates, including one genomic cluster, formed by eleven multidrug resistant isolates and sharing the SIT 3278, which seems to be restricted to Mexico. By the use of WGS, it was possible to identify the high prevalence of L4 and a high number of sublineages circulating in the region, also was recognized the presence of a novel X3 sublineage, formed exclusively by multidrug resistant isolates and with restrictive circulation in Mexico for at least the past 17 years. |
| مصطلحات الفهرس: | artículo |
| URL: | Sí |
| الاتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by/4.0 openAccess |
| ملاحظة: | English |
| Other Numbers: | CTK oai:digital.csic.es:10261/228031 Scientific Reports 11(1):1870 10.1038/s41598-020-80919-5 2045-2322 33479318 1286561610 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1286561610 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |