Electronic Resource
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
| العنوان: | Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense |
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| المؤلفون: | Fundació La Marató de TV3, Australian Research Council, Swiss National Science Foundation, National Health and Medical Research Council (Australia), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Generalitat de Catalunya, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Ministerio de Economía y Competitividad (España), Worldwide Cancer Research, European Commission, Centro Nacional de Investigaciones Cardiovasculares (España), Bosch, Marta, Sánchez-Álvarez, Miguel, Fajardo, Alba, Kapetanovic, Ronan, Steiner, Bernhard, Dutra, Filipe, Moreira, Luciana, López, Juan Antonio, Campo, Rocío, Marí, Montserrat, Morales-Paytuvi, Frederic, Tort, Olivia, Gubern, Albert, Templin, Rachel M., Curson, James E. B., Martel, Nick, Catalá, Cristina, Lozano, Francisco, Tebar, Francesc, Enrich, Carlos, Vázquez, Jesús, Pozo Barriuso, Miguel Ángel del, Sweet, Matthew J., Bozza, Patricia T., Gross, Steven P., Parton, Robert G., Pol, Albert |
| بيانات النشر: | American Association for the Advancement of Science 2020-10-16 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Lipid droplets (LDs) are the major lipid storage organelles of eukaryotic cells and a source of nutrients for intracellular pathogens. We demonstrate that mammalian LDs are endowed with a protein-mediated antimicrobial capacity, which is up-regulated by danger signals. In response to lipopolysaccharide (LPS), multiple host defense proteins, including interferon-inducible guanosine triphosphatases and the antimicrobial cathelicidin, assemble into complex clusters on LDs. LPS additionally promotes the physical and functional uncoupling of LDs from mitochondria, reducing fatty acid metabolism while increasing LD-bacterial contacts. Thus, LDs actively participate in mammalian innate immunity at two levels: They are both cell-autonomous organelles that organize and use immune proteins to kill intracellular pathogens as well as central players in the local and systemic metabolic adaptation to infection. |
| مصطلحات الفهرس: | Lipid droplets, Mitochondria, Innate immunity, Immunometabolism, Proteomics, Antibiotics, Cathelicidins, artículo |
| URL: | Postprint Postprint Sí info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-098593-B-I00 RTI2018-098593-B-I00/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2015-67580-P info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-51876-R info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/SAF2017-83130-R SAF2017-83130-R/AEI/10.13039/501100011033 info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SEV-2015-0505 |
| الاتاحة: | Open access content. Open access content openAccess |
| Other Numbers: | CTK oai:digital.csic.es:10261/224174 Science 370(6514): eaay8085 (2020) 10.1126/science.aay8085 1286558761 |
| المصدر المساهم: | CSIC From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1286558761 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |