Electronic Resource
Surgical versus expectant management in women with an incomplete evacuation of the uterus after treatment with misoprostol for miscarriage: the MisoREST trial
| العنوان: | Surgical versus expectant management in women with an incomplete evacuation of the uterus after treatment with misoprostol for miscarriage: the MisoREST trial |
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| المؤلفون: | Verschoor, M.A., Lemmers, M., Bossuyt, P.M., Graziosi, G.C., Hajenius, P.J., Hendriks, D.J., Hooff, M.A. van, Meurs, H.S. van, Opmeer, B.C., Tulder, M.W. van, Bouwma, L., Catshoek, R., Geomini, P., Klinkert, E.R., Langenveld, J., Nieboer, T.E., Ploeg, J.M. van der, Radder, C.M., Spinder, T., Voet, L.F. van der, Mol, B.W., Huirne, J.A., Ankum, W.M. |
| المصدر: | BMC Pregnancy and Childbirth; 102; 1471-2393; 13; ~BMC Pregnancy and Childbirth~102~~~~1471-2393~~13~~ |
| بيانات النشر: | 2013 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Contains fulltext : 117709.pdf (publisher's version ) (Open Access) BACKGROUND: Medical treatment with misoprostol is a non-invasive and inexpensive treatment option in first trimester miscarriage. However, about 30% of women treated with misoprostol have incomplete evacuation of the uterus. Despite being relatively asymptomatic in most cases, this finding often leads to additional surgical treatment (curettage). A comparison of effectiveness and cost-effectiveness of surgical management versus expectant management is lacking in women with incomplete miscarriage after misoprostol. METHODS/DESIGN: The proposed study is a multicentre randomized controlled trial that assesses the costs and effects of curettage versus expectant management in women with incomplete evacuation of the uterus after misoprostol treatment for first trimester miscarriage.Eligible women will be randomized, after informed consent, within 24 hours after identification of incomplete evacuation of the uterus by ultrasound scanning. Women are randomly allocated to surgical or expectant management. Curettage is performed within three days after randomization.Primary outcome is the sonographic finding of an empty uterus (maximal diameter of any contents of the uterine cavity < 10 millimeters) six weeks after study entry. Secondary outcomes are patients' quality of life, surgical outcome parameters, the type and number of re-interventions during the first three months and pregnancy rates and outcome 12 months after study entry. DISCUSSION: This trial will provide evidence for the (cost) effectiveness of surgical versus expectant management in women with incomplete evacuation of the uterus after misoprostol treatment for first trimester miscarriage. TRIAL REGISTRATION: Dutch Trial Register: NTR3110. |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| Other Numbers: | NLQGE oai:repository.ubn.ru.nl:2066/117709 https://repository.ubn.ru.nl//bitstream/handle/2066/117709/117709.pdf 1284172002 |
| المصدر المساهم: | RADBOUD UNIVERSITEIT NAJMEGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1284172002 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |