Electronic Resource
Cognitive consequences of regression of cerebral small vessel disease
| العنوان: | Cognitive consequences of regression of cerebral small vessel disease |
|---|---|
| المؤلفون: | Leijsen, E.M.C. van, Bergkamp, M.I., Uden, I.W.M. van, Cooijmans, S., Ghafoorian, M., Holst, H.M. van der, Norris, D.G., Kessels, R.P.C., Platel, B., Tuladhar, A.M., Leeuw, F.E. de |
| المصدر: | European Stroke Journal; 85; 89; 2396-9873; 1; 4; ~European Stroke Journal~85~89~~~2396-9873~1~4~~ |
| بيانات النشر: | 2019 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Contains fulltext : 201918.pdf (publisher's version ) (Closed access) Introduction: Recent studies have shown that neuroimaging markers of cerebral small vessel disease can also regress over time. We investigated the cognitive consequences of regression of small vessel disease markers. Patients and methods: Two hundred and seventy-six participants of the RUNDMC study underwent neuroimaging and cognitive assessments at three time-points over 8.7 years. We semi-automatically assessed white matter hyperintensities volumes and manually rated lacunes and microbleeds. We analysed differences in cognitive decline and accompanying brain atrophy between participants with regression, progression and stable small vessel disease by analysis of variance. Results: Fifty-six participants (20.3%) showed regression of small vessel disease markers: 31 (11.2%) white matter hyperintensities regression, 10 (3.6%) vanishing lacunes and 27 (9.8%) vanishing microbleeds. Participants with regression showed a decline in overall cognition, memory, psychomotor speed and executive function similar to stable small vessel disease. Participants with small vessel disease progression showed more cognitive decline compared with stable small vessel disease (p < 0.001 for cognitive index and memory; p < 0.01 for executive function), although significance disappeared after adjusting for age and sex. Loss of total brain, gray matter and white matter volume did not differ between participants with small vessel disease regression and stable small vessel disease, while participants with small vessel disease progression showed more volume loss of total brain and gray matter compared to those with stable small vessel disease (p < 0.05), although significance disappeared after adjustments. Discussion: Regression of small vessel disease markers was associated with similar cognitive decline compared to stable small vessel disease and did not accompany brain atrophy, suggesting that small vessel disease regression follows a relatively benign clinical course. Future studies are requ |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| Other Numbers: | NLQGE oai:repository.ubn.ru.nl:2066/201918 https://doi.org/10.1177/2396987318820790 1284104898 |
| المصدر المساهم: | RADBOUD UNIVERSITEIT NAJMEGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1284104898 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |