Electronic Resource
Synthesis, structural characterisation and cytotoxicity study of tin(IV) compounds containing ONS Schiff bases
| العنوان: | Synthesis, structural characterisation and cytotoxicity study of tin(IV) compounds containing ONS Schiff bases |
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| المؤلفون: | Md Yusof, Enis Nadia |
| بيانات النشر: | 2019-12 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | There is an urgent need for substantial investigation of non-platinum drugs with higher activity and improved selectivity to address the problem associated with the use of platinum-based compounds as therapeutic agents. In light of this, diphenyltin(IV), dimethyltin(IV) and tin(IV) compounds were synthesised from the Schiff bases of three series of dithiocarbazate (S-2-methylbenzyldithiocarbazate (S1), S-4-methylbenzyl dithiocarbazate (S2), S-benzyldithiocarbazate (S3)) and two series of thiosemicarbazides (4-methyl-3-thiosemicarbazide and 4-phenyl-3- thiosemicarbazide) with aldehydes, 2-hydroxy-3-methoxybenzaldehyde (oVa) or 2,3-dihydroxybenzaldehyde (catechol). The tin(IV) compounds formed were found to have a general formula of [R2Sn(ONS)] and [Sn(ONS)2] (where R = Me and Ph). The compounds were fully characterised by physico-chemical and spectroscopic methods. The spectroscopic results supported the coordination geometry in which the Schiff bases behaved as tridentate ONS donor ligands coordinating via azomethine nitrogen, thiolo sulphur and phenoxide oxygen atoms. A total of 11 crystal structures of the expected compounds were solved in this work. In order to verify the experimental data, the compounds were optimised using the density functional theory (DFT) method with the B3LYP hybrid exchange correlation functional with LanL2DZ pseudopotential on tin and 6-311G(d,p) Pople basis set for all other atoms. Diphenyltin(IV) compounds showed the most promising cytotoxicity with IC50 values ranging between 0.016 – 4.40 μM against a panel of twelve cancer cell lines (RT-112, EJ-28 (bladder), HT29 (colon), U87, SJ-G2, SMA (glioblastoma), MCF-7 (breast), A2780 (ovarian), H460 (lung), A431 (skin), Du145 (prostate), BE2-C (neuroblastoma) and MIA (pancreatic)). The three diphenyltin(IV) compounds of the oVa series were able to induce the production of Reactive Oxygen Species (ROS) and acted as a cell apoptosis inducer. Good binding interactions for all the diphenyltin(IV) |
| مصطلحات الفهرس: | Organotin compounds, Schiff bases, Tin compounds, Thesis, NonPeerReviewed |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | text English |
| Other Numbers: | MYPUT oai:psasir.upm.edu.my:90030 Md Yusof, Enis Nadia (2019) Synthesis, structural characterisation and cytotoxicity study of tin(IV) compounds containing ONS Schiff bases. Doctoral thesis, Universiti Putra Malaysia. 1261876818 |
| المصدر المساهم: | UNIVERSITI PUTRA MALAYSIA From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1261876818 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |