Electronic Resource
Do high MICs predict the outcome in invasive fusariosis?
| العنوان: | Do high MICs predict the outcome in invasive fusariosis? |
|---|---|
| المؤلفون: | Nucci, M., Jenks, J., Thompson, G. R., Hoenigl, M., Dos Santos, M. C., Forghieri, F., Rico, J. C., Bonuomo, V., Lopez-Soria, L., Lass-Florl, C., Candoni, A., Garcia-Vidal, C., Cattaneo, C., Buil, J., Rabagliati, R., Roiz, M. P., Gudiol, C., Fracchiolla, N., Campos-Herrero, M. I., Delia, M., Farina, F., Fortun, J., Nadali, G., Sastre, E., Colombo, A. L., Perez Nadales, E., Alastruey-Izquierdo, A., Pagano, Livio, Pagano L. (ORCID:0000-0001-8287-928X) |
| بيانات النشر: | NLM (Medline) 2021 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: Invasive fusariosis (IF) affects mostly severely immunocompromised hosts and is associated with poor outcome. Since Fusarium species exhibit high MICs for most antifungal agents, this could explain the poor prognosis. However, a clear-cut correlation between MIC and outcome has not been established. OBJECTIVE: To evaluate the correlation between MIC and outcome (6 week death rate) in patients with IF. METHODS: We performed a multicentre retrospective study of patients with IF who received treatment and had MIC levels determined by EUCAST or CLSI for the drug(s) used during treatment. We compared the MIC50 and MIC distribution among survivors and patients who died within 6 weeks from the diagnosis of IF. RESULTS: Among 88 patients with IF, 74 had haematological diseases. Primary treatment was monotherapy in 52 patients (voriconazole in 27) and combination therapy in 36 patients (liposomal amphotericin B + voriconazole in 23). The MIC50 and range for the five most frequent agents tested were: voriconazole 8 mg/L (range 0.5-64), amphotericin B 2 mg/L (range 0.25-64), posaconazole 16 mg/L (range 0.5-64), itraconazole 32 mg/L (range 4-64), and isavuconazole 32 mg/L (range 8-64). There was no difference in MIC50 and MIC distribution among survivors and patients who died. By contrast, persistent neutropenia and receipt of corticosteroids were strong predictors of 6 week mortality. CONCLUSIONS: Our study did not show any correlation between MIC and mortality at 6 weeks in patients with IF. |
| مصطلحات الفهرس: | fusariosis, Settore MED/15 - MALATTIE DEL SANGUE, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/33326585 info:eu-repo/semantics/altIdentifier/wos/WOS:000648949200032 volume:76 issue:4 firstpage:1063 lastpage:1069 numberofpages:7 issueyear:2020 journal:JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | SYC oai:publicatt.unicatt.it:10807/175669 10.1093/jac/dkaa516 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85102964251 1256809534 |
| المصدر المساهم: | UNIV CATTOLICA DEL SACRO CUORE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1256809534 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |