Electronic Resource
Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts
| العنوان: | Radiation treatment monitoring with DCE-US in CWR22 prostate tumor xenografts |
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| المؤلفون: | Arteaga-Marrero, Natalia, Mainou-Gomez, Jose F., Rygh, Cecilie Brekke, Lutay, Nataliya, Roehrich, Dieter, Reed, Rolf K., Olsen, Dag R. |
| بيانات النشر: | Umeå universitet, Radiofysik Department of Physics and Technology, University of Bergen, Bergen, Norway 2019 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Longitudinal monitoring of potential radiotherapy treatment effects can be determined by dynamic contrast-enhanced ultrasound (DCE-US). Purpose: To assess functional parameters by means of DCE-US in a murine subcutaneous model of human prostate cancer, and their relationship to dose deposition and time-frame after treatment. A special focus has been placed to evaluate the vascular heterogeneity of the tumor and on the most suitable data analysis approach that reflects this heterogeneity. Material and Methods: In vivo DCE-US was acquired 24 h and 48 h after radiation treatment with a single dose of 7.5 Gy and 10 Gy, respectively. Tumor vasculature was characterized pixelwise using the Brix pharmacokinetic analysis of the time-intensity curves. Results: Longitudinal changes were detected (P < 0.001) at 24 h and 48 h after treatment. At 48 h, the eliminating rate constant of the contrast agent from the plasma, kel, was correlated (P ≤ 0.05) positively with microvessel density (MVD; rτ = 0.7) and negatively with necrosis (rτ = –0.6) for the treated group. Furthermore, Akep, a parameter related to transcapillary transport properties, was also correlated to MVD (rτ = 0.6, P ≤ 0.05). Conclusion: DCE-US has been shown to detect vascular changes at a very early stage after radiotherapy, which is a great advantage since DCE-US is non-invasive, available at most hospitals, and is low in cost compared to other techniques used in clinical practice. |
| مصطلحات الفهرس: | Dynamic contrast-enhanced ultrasound, DCE-US, ultrasound, CWR22, prostate, cancer, Radiology, Nuclear Medicine and Medical Imaging, Radiologi och bildbehandling, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1177.0284185118798167 |
| URL: | Acta Radiologica, 0284-1851, 2019, 60:6, s. 788-797 |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| Other Numbers: | UPE oai:DiVA.org:umu-160290 doi:10.1177/0284185118798167 PMID 30231620 ISI:000469519900015 1234604723 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1234604723 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1177.0284185118798167 |
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