Electronic Resource
Acute effects of different dietary fatty acids on the gene expression profiles of PBMCs of healthy young men
| العنوان: | Acute effects of different dietary fatty acids on the gene expression profiles of PBMCs of healthy young men |
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| المؤلفون: | Bouwens, Mark, Grootte Bromhaar, Mechteld, Jansen, Jenny, Muller, Michael, Afman, Lydia |
| بيانات النشر: | Wageningen University 2010 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Acute effects of different dietary fatty acids on the gene expression profiles of peripheral blood mononuclear cells in healthy young men. A randomized cross-over study. Acute effects of different dietary fatty acids on the gene expression profiles of peripheral blood mononuclear cells in healthy young men. A randomized cross-over study. Gene expression profiles of peripheral blood mononuclear cells (PBMCs) have been used to reflect pathological and physiological states of humans. We theorized that these cells could also be used to show fatty acid specific gene expression profiles. Since most individuals are in a postprandial state for the main part of the day, knowledge about acute effects of diet is highly valuable. In a cross over study, 21 healthy male volunteers were given shakes containing mainly polyunsaturated or saturated fatty acids. Before and 6 hours after intake of the shakes blood was taken and PBMCs were isolated to use for whole genome gene expression profiling, using Affymetrix NuGO_Hs1a52018 arrays. PUFA intake showed an decrease in LXR signaling and an increase in cellular stress response, while SFA intake showed an increase in LXR signaling.We conclude that PBMCs can reveal a fatty acid specific gene expression profile and in this study show an adverse effect on cellular stress responses of immune cells upon high PUFA intake. We hypothesize that these cells can therefore be used as biomarkers to reflect the capacity of cells to response to cellular stressors, such as fatty acids. |
| مصطلحات الفهرس: | Homo sapiens, Dataset |
| URL: | |
| الاتاحة: | Open access content. Open access content Wageningen University & Research |
| ملاحظة: | text/html |
| Other Numbers: | NLWUP oai:library.wur.nl:wurpubs/530928 https://research.wur.nl/en/datasets/acute-effects-of-different-dietary-fatty-acids-on-the-gene-expres 1200336502 |
| المصدر المساهم: | WUR STAFF PUBNS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1200336502 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |