Electronic Resource
Computerized Hand Grip Myometry Reliably Measures Myotonia and Strength in Myotonic Dystrophy (DM1) and Myotonia Correlates Directly with CTG Repeat Size of the DM1 Gene
| العنوان: | Computerized Hand Grip Myometry Reliably Measures Myotonia and Strength in Myotonic Dystrophy (DM1) and Myotonia Correlates Directly with CTG Repeat Size of the DM1 Gene |
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| المؤلفون: | Thornton, CA, Moxley III, RT, Martens, WB, Logigian, EL, Blood, BS, Dilek, N, Barbieri, RN, Wiegner, AW, Moxley IV, RT |
| بيانات النشر: | Fri, 26 Oct 2007 18:49:25 Year: 2006 Wed, 26 Sep 2012 16:35:14 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Poster presented at the April 2006 AAN Conference in San Diego, CA. OBJECTIVE To develop a reliable, sensitive, quantitative measure of grip myotonia and strength in DM1 using an electronic isometric grip myometer; and to compare such a measure with leukocyte CTG repeat size of the DM1 gene and with whole body muscle strength and function. BACKGROUND DM1 is a multisystem, dominantly inherited disease caused by an unstable CTG repeat expansion in the 3’ non-translated region of DM1 gene on chromosome 19. Myotonia, weakness of facial and distal limb muscles, and cataracts are core clinical findings. Methods to quantitate grip myotonia and strength are needed to assess the natural history of these manifestations and to evaluate potential treatments. |
| مصطلحات الفهرس: | DM1, hand grip myometer, Harvard Medical School, University of Rochester Department of Neurology, grip myotonia, myotonia, Myotonic Dystrophy |
| URL: | |
| الاتاحة: | Open access content. Open access content This item is protected by copyright, with all rights reserved. |
| ملاحظة: | English |
| Other Numbers: | RRR oai:urresearch.rochester.edu:4253 1138023573 |
| المصدر المساهم: | UNIV OF ROCHESTER From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1138023573 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |