Electronic Resource
Lipid nanocapsules as in vivo oxygen sensors using magnetic resonance imaging.
| العنوان: | Lipid nanocapsules as in vivo oxygen sensors using magnetic resonance imaging. |
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| المؤلفون: | UCL - SSS/LDRI - Louvain Drug Research Institute, Nel, Janske, Franconi, Florence, Joudiou, Nicolas, Saulnier, Patrick, Gallez, Bernard, Lemaire, Laurent |
| المصدر: | Materials science & engineering. C, Materials for biological applications, Vol. 101, no.Aug, p. 396-403 (2019) |
| بيانات النشر: | 2019 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Hypoxia is common occurrence of the tumour microenvironment, wherein heterogeneous gradients of O give rise to tumoural cells which are highly malignant, metastatic, and resistant to therapeutic efforts. Thus, the assessment and imaging of hypoxia is essential for tumour diagnosis and treatment. Magnetic resonance imaging and, more specifically, the quantitative assessment of longitudinal relaxation time enhancement, was shown to enable the mapping of oxygen in tumours with increased sensitivity for lipids as compared to water signal. Unfortunately, this can only be applied to tumours with high lipid content. To overcome this issue, we propose the use of lipid nanocapsules (LNCs). LNCs have been demonstrated as excellent core-shell nanocarriers, wherein the lipidic-core is used for lipophilic drug encapsulation, enabling treatment of highly malignant tumours. Herein, however, we exploited the lipidic-core of the LNCs to develop a simple but effective technique to increase the lipidic content within tissues to enable the assessment and mapping of pO. LNCs were prepared using the phase-inversion technique to produce 60 nm sized nanoparticles, and in vitro studies demonstrated the permeability and responsiveness of LNCs to O. To evaluate the ability of LNCs to respond to changes in pOin vivo, after a hyperoxic challenge, three animal models, namely a normal tissue model (gastrocnemius muscle tissue) and two tumour tissue models (subcutaneous fibrosarcoma and intracerebral glioblastoma) were explored. LNCs were found to be responsive to variation of Oin vivo. Moreover, the use of MRI enabled the mapping of oxygen gradients and heterogeneity within tumours. |
| مصطلحات الفهرس: | Carbogen challenge, Hypoxia, Lipid nanocapsules, Magnetic resonance imaging, info:eu-repo/semantics/article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | English |
| Other Numbers: | UCDLC oai:dial.uclouvain.be:boreal:217341 boreal:217341 info:doi/10.1016/j.msec.2019.03.104 info:pmid/31029333 urn:EISSN:1873-0191 1130443848 |
| المصدر المساهم: | UNIVERSITE CATHOLIQUE DE LOUVAIN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1130443848 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |