Electronic Resource
Long Term Memory Profile of Disorders Associated with Dysregulation of the RAS-MAPK Signaling Cascade.
| العنوان: | Long Term Memory Profile of Disorders Associated with Dysregulation of the RAS-MAPK Signaling Cascade. |
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| المؤلفون: | Alfieri, Paolo, Cesarini, L, Mallardi, Maria, Piccini, G, Caciolo, C, Leoni, Chiara, Mirante, N, Pantaleoni, F, Digilio, Mc, Gambardella, Maria Luigia, Tartaglia, Marco, Vicari, S, Mercuri, Eugenio Maria, Zampino, Giuseppe, Mercuri, Eugenio Maria (ORCID:0000-0002-9851-5365), Zampino, Giuseppe (ORCID:0000-0003-3865-3253) |
| بيانات النشر: | country:USA 2011 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | In the present study we evaluated long term memory in twenty individuals with molecularly confirmed diagnosis of Noonan syndrome and LEOPARD syndrome, two disorders caused by mutations in genes coding transducers participating in the RAS-MAPK signaling cascade. The profile of explicit long term memory abilities was investigated using PROMEA, which includes a battery of tests specifically developed to assess memory and learning in verbal, visual and spatial domains. Ten individuals (50%) had impaired (≤5th percentile) or below average (≤15th percentile) performance on a delayed verbal free recall memory task, four (20%) on a delayed visual recognition memory task, and only one (5%) on a delayed spatial recognition memory task. Our data suggest that dysregulation of the RAS-MAPK cascade may be associated with a pattern of reduced verbal recall memory performance but relative sparing of visual and spatial recognition memory. |
| مصطلحات الفهرس: | RAS-MAPK, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/wos/WOS:000291035400010 volume:2011 issue:Gennaio firstpage:423 lastpage:429 numberofpages:7 issueyear:2011 journal:BEHAVIOR GENETICS |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | SYC oai:publicatt.unicatt.it:10807/4841 10.1007/s10519-011-9446-5 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79958194158 1104999404 |
| المصدر المساهم: | UNIV CATTOLICA DEL SACRO CUORE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1104999404 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |