Electronic Resource
Accuracy of multidetector-row CT for restaging after neoadjuvant treatment in patients with oesophageal cancer
| العنوان: | Accuracy of multidetector-row CT for restaging after neoadjuvant treatment in patients with oesophageal cancer |
|---|---|
| المؤلفون: | Konieczny, Agnieszka, Meyer, Philipp, Schnider, Annelies, Komminoth, Paul, Schmid, Mathias, Lombriser, Norbert, Weishaupt, Dominik |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Objectives: To assess the diagnostic accuracy of 64-multidetector CT (MDCT) for restaging of patients with oesophageal cancer undergoing neoadjuvant therapy. Methods: Results of pathological staging were correlated with those from 64-MDCT before and after neoadjuvant treatment in 35 patients using the American Joint Committee on Cancer/TNM classification (7th edition). CT response was determined using the Response Evaluation Criteria in Solid Tumours (RECIST) method, modified for one-dimensional tumour diameter measurement. Results: 64-MDCT predicted T stage correctly in 34% (12/35), overstaged in 49% (17/35) and understaged in 17% (6/35). Sensitivity/specificity values were as follows: T0, 20%/92%; T1-T2, 31%/59%; T3, 60%/64%; T4, 100%/4%. Negative predictive values for T3/T4 were 80%/100%. MDCT accurately predicted complete histopathological response in 20% (accuracy 74%) and overstaged in 80%. Tumour regression grade was predicted correctly in only 8% (2/25) and underestimated in 68% (17/25). Accurate N stage was noted in 69% (24/35). Conclusion: Although MDCT tends to be able to exclude advanced tumour stages (T3, T4) with a higher likelihood, the diagnostic accuracy of high resolution MDCT for restaging oesophageal cancer and assessing the response to neoadjuvant therapy has not improved in comparison to older-generation CT. Therefore, the future assessment of oesophageal tumour response should focus on combined morphologic and metabolic imaging. Key Points : • Multidetector CT (MDCT) has been beneficial for the evaluation of many tumours. • However diagnostic accuracy for restaging oesophageal cancer has not improved with MDCT. • MDCT tends to be able to exclude advanced tumour stages (T3/T4). • MDCT has a low accuracy for determining lymph node metastasis. • Oesophageal tumour response should be assessed by combined morphological and metabolic imaging |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| Other Numbers: | CHRRO oai:doc.rero.ch:313292 1043538681 |
| المصدر المساهم: | RERO-LIBR NETWORK OF WESTERN SWITZERLAND From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1043538681 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |