Electronic Resource
Induction and patterning of the Purkinje fiber network
| العنوان: | Induction and patterning of the Purkinje fiber network |
|---|---|
| المؤلفون: | Runge, Marschall S., Patterson, Cam, Mikawa, Takashi, Gourdie, Robert G., Takebayashi-Suzuki, Kimiko, Kanzawa, Nobuyuki, Pennisi, David J., Poma, Clifton P., Shulimovich, Maxim |
| المصدر: | Principles of Molecular Cardiology |
| بيانات النشر: | Humana Press 2005 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Our studies in the embryonic chick heart have shown that impulse-conducting Purkinje cells differentiate from myocytes during embryogenesis. This conversion of contractile myocytes into conduction cells is induced by paracrine signals, such as endothelin (ET), derived from the endocardium and developing coronary arteries. Active ET is secreted through proteolytic processing from its precursor by ET-converting enzyme-1 (ECE-1) and triggers signaling by binding to its receptors. In the embryonic heart, two ET receptors, ETA and ETB, are expressed by myocytes. ECE-1 is predominantly expressed in endothelial cells of the endocardium and coronary arteries, but not in veins or capillaries. Furthermore, retroviral co-expression of exogenous ECE-1 with ET precursor in the embryonic heart is sufficient to induce ectopic myocyte conversion to conduction cells. Thus, localized expression of ECE-1 in endocardial and arterial endothelia is a key mechanism defining the site of Purkinje fiber recruitment in the embryonic myocardium. Inhibition of endogenous ECE-1 expression via suppression of stretch-sensitive channels results in down-regulated expression of Purkinje fiber markers. This finding suggests that biophyical forces acted on, and created by, the cardiovascular system during embryogenesis may play a critical role in induction and patterning of Purkinje fibers. |
| مصطلحات الفهرس: | Chapter in Book, Report or Conference volume |
| URL: | doi:10.1007/978-1-59259-878-6_18 Mikawa, Takashi, Gourdie, Robert G., Takebayashi-Suzuki, Kimiko, Kanzawa, Nobuyuki, Pennisi, David J., Poma, Clifton P., & Shulimovich, Maxim (2005) Induction and patterning of the Purkinje fiber network. In Runge, Marschall S. & Patterson, Cam (Eds.) Principles of Molecular Cardiology. Humana Press, Totowa, NJ, pp. 311-321. |
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| Other Numbers: | ATUTQ oai:eprints.qut.edu.au:107497 Faculty of Health 1004815366 |
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| رقم الانضمام: | edsoai.on1004815366 |
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