Electronic Resource
Diagnostic accuracy of C-terminal fragment of type I procollagen in detection of hidden heart failure in hypertensive males.
| العنوان: | Diagnostic accuracy of C-terminal fragment of type I procollagen in detection of hidden heart failure in hypertensive males. |
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| المؤلفون: | Kolesnyk, M. Yu. |
| المصدر: | Medicni perspektivi (Medical perspectives); Том 20, № 1 (2015); 35-41; Медичні перспективи; 2307-0404 |
| بيانات النشر: | SE "Dnipropetrovsk medical academy of Health Ministry of Ukraine" 2015-03-16 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Purpose: to estimate diagnostic accuracy of C-terminal fragment of type I procollagen (PICP) in hypertensive males with hidden chronic heart failure (CHF). The study included 220 men with uncomplicated arterial hypertension (mean age 52 (46-58) years). The control group consisted of 40 healthy men of similar age. Ambulatory blood pressure monitoring, transthoracic echocardiography and speckle tracking echocardiography was performed to all participants. All patients underwent treadmill test with post-exercise evaluation of left ventricular (LV) filling pressure by tissue Doppler Е/е' ratio to reveal hidden CHF. The post-exercise Е/е'≥13 was considered to be pathological. PICP levels in plasma were determined by ELISA. The PICP concentration was significantly higher in men with hypertension (132,3 (81,3-216,8) ng/ml) as compared with healthy subjects (93.2 (64,7-133) ng/ml) (p=0,0068). The presence of LV hypertrophy did not affect the level of PICP (p=0,58). 16 patients presented pathological result of diastolic stress test revealing signs of hidden heart failure. PICP concentration was 2-fold higher in these individuals as compared with other patients (p=0.01). The ROC-analysis revealed, that optimal cut-off point is 170.2 ng/ml for PICP to detect hidden CHF (area under curve – 0,68±0,08; 95% confidence interval – 0,61-0,74; sensitivity – 68,7%, specificity – 69,6%). The PICP level exceeding 170,2 ng/mL testifies to hidden CHF in hypertensive males. |
| مصطلحات الفهرس: | arterial hypertension, myocardial stiffness, collagen I, chronic heart failure, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | |
| الاتاحة: | Open access content. Open access content Copyright (c) 2017 Medical Perspectives Copyright (c) 2017 Медичні перспективи http://creativecommons.org/licenses/by-nc/4.0 |
| ملاحظة: | application/pdf Medicni perspektivi (Medical perspectives) English |
| Other Numbers: | UANTU oai:ojs.journals.uran.ua:article/40236 987588877 |
| المصدر المساهم: | NATIONAL TECH UNIV OF UKRAINE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn987588877 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |