Electronic Resource
GRANULOMATOZA S POLIANGIITISOM (GPA) I LOKALIZIRANIM ZAHVAĆANJEM GORNJEGA DIŠNOG SUSTAVA – PRIKAZ BOLESNICE
| العنوان: | GRANULOMATOZA S POLIANGIITISOM (GPA) I LOKALIZIRANIM ZAHVAĆANJEM GORNJEGA DIŠNOG SUSTAVA – PRIKAZ BOLESNICE |
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| Additional Titles: | GRANULOMATOSIS WITH POLYANGIITIS (GPA) LIMITED TO UPPER RESPIRATORY TRACT – A CASE REPORT |
| المؤلفون: | Ivan Marković, Silva Pukšić, Ana Gudelj-Gračanin, Ivan Ožegović, Melanie-Ivana Čulo, Joško Mitrović, Jadranka Morović-Vergles |
| المصدر: | Liječnički vjesnik; ISSN 0024-3477 (Print); ISSN 1849-2177 (Online); Volume 138; Issue 1-2 |
| بيانات النشر: | Croatian medical association 2016 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Granulomatoza s poliangiitisom (Wegenerova granulomatoza) ubraja se u vaskulitise malih krvnih žila povezane s antineutrofilnim citoplazmatskim protutijelima. Najčešće su zahvaćeni gornji i donji dišni sustav te bubrezi. Obilježja bolesti uključuju granulomatoznu upalu dišnog sustava i nekrotizirajući vaskulitis malih do srednje velikih krvnih žila. U većine je bolesnika pri postavljanju dijagnoze zahvaćeno više organskih sustava te mogu biti prisutni i opći simptomi, dok je u oko četvrtine bolesnika inicijalno prisutan lokalizirani oblik bolesti sa zahvaćanjem najčešće gornjega dišnog sustava ili pluća. U radu smo prikazali dvadesetjednogodišnju bolesnicu s kroničnim rinitisom, razvojem sedlaste deformacije nosa i subglotičnom stenozom traheje koja je hospitalizirana zbog inspiratornog stridora. Zbog respiratorne insuficijencije učinjena je hitna traheotomija. U bolesnice je dijagnosticirana granulomatoza s poliangiitisom ograničena na gornji dišni sustav. Liječenje glukokortikoidima i metotreksatom dovelo je do kliničkog poboljšanja. Granulomatosis with polyangiitis (Wegener’s granulomatosis) is one of the anti-neutrophil cytoplasmic antibody-associated small vessel vasculitides. Upper and lower respiratory system and kidneys are most commonly affected. The disease is characterized by granulomatous inflammation of the respiratory tract and necrotizing vascu-litis of small to medium-sized blood vessels. Most patients show involvement of more than one organ systems at the time of diagnosis, and constitutional symptoms may be present. In around a quarter of patients the disease is initially localised, with involvement of upper respiratory tract or lungs. We report a 21-year-old female patient with chronic rhinitis, saddle nose deformity and subglottic stenosis who presented with inspiratory stridor and impending respirato-ry failure. Initially, urgent tracheotomy was performed. The patient was diagnosed with granulomatosis with polyan-giitis limited to upper respiratory tract. Treatment with glucocorticoids and methotrexate was followed by clinical improvement. |
| مصطلحات الفهرس: | Granulomatoza s poliangiitisom – dijagnoza, komplikacije, imunologija, farmakoterapija; Laringostenoza – etiologija, komplikacije; Respiracijski zvukovi – etiologija; Traheotomija; Metotreksat – terapijska primjena; Imunosupresijski lijekovi – terapijska primjena; Glukokortikoidi – terapijska primjena; Nosne stečene deformacije – etiologija; Nosna sluznica – patologija, Granulomatosis with polyangiitis – diagnosis, complications, immunology, drug therapy; Laryngostenosis – etiology, complications; Respiratory sounds – etiology; Tracheotomy; Methotrexate – therapeutic use; Immunosuppressive agents – therapeutic use; Glucocorticoids – therapeutic use; Nose deformities, acquired – etiology; Nasal mucosa – pathology, text, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess The Medical Journal is an open access journal. The content of the magazine is available in its entirety free of charge. The contents of the Medical Journal may be reproduced with the quotation "taken from the Medical Journal". Users may not use the materials for commercial purposes, may not modify, redesign or rework the material. |
| ملاحظة: | application/pdf Croatian |
| Other Numbers: | HRCAK oai:hrcak.srce.hr:172830 985177899 |
| المصدر المساهم: | HRCAK PORTAL ZNANSTVENIH CASOPISA REPUB From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn985177899 |
| قاعدة البيانات: | OAIster |
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