Electronic Resource
Prevalencia y factores asociados al virus de la Diarrea Epidémica Porcina (PEDv) en transporte de cerdos a plantas de beneficio en Colombia
العنوان: | Prevalencia y factores asociados al virus de la Diarrea Epidémica Porcina (PEDv) en transporte de cerdos a plantas de beneficio en Colombia |
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المؤلفون: | Trillos, Carlos Enrique, Zambrano Moreno, Diana Corina, Pineda Otiz, María del Pilar, Corrales Morales, Johanna |
المصدر: | instname:Universidad del Rosario; reponame:Repositorio Institucional EdocUR; OIE. Infección por el virus de Diarrea Epidemica Porcina. Ficha tecnica de la OIE. 2014 Sep;1–4.; Cima Greg. PED virus reinfecting U.S. herds. J Am Vet Med Assoc [Internet]. 2014;245(2). Available from:; USDA. Swine Enteric Coronavirus Disease (SECD) Situation Report - Oct 22 [Internet]. 2015. Available from:; USDA NASS-N-USD of A-U. Quarterly Hogs and Pigs -2014 [Internet]. 2014. Available from:; Mathews K. Livestock, Dairy, and Poultry Outlook - Feb 2014 [Internet]. 2014. Available from:; OIE -WAHID. Eventos epidemiologicos de caracter excepcional - Mexico - 2014 diarrea epidémica porcina [Internet]. 2014. Available from:; Peru S. Boletín Epidemiológico SENASA Octubre [Internet]. Lima - Peru; 2013. Available from:; OIE -WAHID. Diarrea Epidemica Porcina - República Dominicana [Internet]. 2014. Available from:; OIE -WAHID. Diarrea Epidemica Porcina - Ecuador [Internet]. 2014. Available from:; OIE -WAHID. Eventos epidemiologicos caracter excepcional 2014 Colombia diarrea epidemica porcina [Internet]. 2014. Available from:; Asoporcicultores/ FNP. Boletin Sanitario Trimestral No 1 [Internet]. Bogotá DC; 2015. Available from:; Area de Erradicación de PPC Asoporcicultores/ FNP. Boletin Epidemiologico No 12, Avance de la situación epidemiológica de la Diarrea Epidemica Porcina en Colombia [Internet]. Bogotá DC; 2015. Available from:; Porcicolegas. Manejo exitoso de un caso clínico de PEDv en Antioquia. In: Seminario de experiencias exitosas en Sanidad porcina en Colombia. Bogotá, Pereira, Medellin - Colombia: Asoporcicultores/FNP; 2015.; Lowe J, Gauger P, Harmon K, Zhang J, Connor J, Yeske P, et al. Role of transportation in spread of porcine epidemic diarrhea virus infection, United States. Emerg Infect Dis. 2014;20(5):872–4.; Lowe J. The Role of Harvest Plant Lairage and Transportation in Propagating the Initial Stages of an Outbreak of Porcine Epidemic Diarrhea Virus in the United States in 2013– Preliminary Results [Internet]. Urbana IL; 2013. Available from:; Mejia RS. Balance preliminar de 2015 y perspectivas de 2016 [Internet]. Bogotá DC; 2016. Available from: Balance preliminar de 2015 y perspectivas de 2016; Fondo Nacional de la Porcicultura. Análisis de coyuntura del sector porcicultor año 2015. 2016;57(66):16. Available from:; ICA. Censos Porcinos en Colombia [Internet]. Bogotá DC; 2015. Available from:; Baek P-S, Choi H-W, Lee S, Yoon I-J, Lee YJ, Lee DS, et al. Efficacy of an inactivated genotype 2b porcine epidemic diarrhea virus vaccine in neonatal piglets. Vet Immunol Immunopathol [Internet]. 2016;174:45–9. Available from:; Zimmermman, Jeffrey, karriker Locke A, Ramirez Alejandro SKJ and SGWE. Diseases of Swine. Disease of Swine: 9th Edition. Ames, Iowa: Blackwell Publishing,. 2012. 1-983 p.; Pan Y, Tian X, Li W, Zhou Q, Wang D, Bi Y, et al. Isolation and characterization of a variant porcine epidemic diarrhea virus in China. Virol J. 2012;9:195.; Lee S, Kim Y, Lee C. Isolation and characterization of a Korean porcine epidemic diarrhea virus strain KNU-141112. Virus Res. 2015;208:215–24.; V. Ausina Ruiz y S. Moreno Guillén. Infecciones por Rinovirus y coronavirus. In: Panamericana EM, editor. Tratado SEIMC de Enfermedades Infecciosas y Microbiología Clínica [Internet]. Madrid; p. 873–83. Available from:; Lee C. Porcine epidemic diarrhea virus : An emerging and re-emerging epizootic swine virus. Virol J [Internet]. 2015;1–16. Available from:; Lee DK, Park CK, Kim SH, Lee C. Heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in Korea. Virus Res [Internet]. 2010;149(2):175–82. Available from:; Song DS, Yang JS, Oh JS, Han JH, Park BK. Differentiation of a Vero cell adapted porcine epidemic diarrhea virus from Korean field strains by restriction fragment length polymorphism analysis of ORF 3. Vaccine. 2003;21(17–18):1833–42.; Park SJ, Moon HJ, Luo Y, Kim HK, Kim EM, Yang JS, et al. Cloning and further sequence analysis of the ORF3 gene of wild- and attenuated-type porcine epidemic diarrhea viruses. Virus Genes. 2008;36(1):95–104.; Song D, Park B. Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines. Virus Genes [Internet]. 2012;44(2):167–75. Available from:; Lee S, Lee C. Outbreak-Related Porcine Epidemic Diarrhea Virus Strains Similar to US strains, South Korea,2013. Emerg Infect Dis. 2014;20(7):1223–6.; Wang S, Cheng X, Chen S, Lin F, Jiang B, Zhu X, et al. Classification of Emergent U.S. Strains of Porcine Epidemic Diarrhea Virus by Phylogenetic Analysis of Nucleocapsid and ORF3 Genes: FIG 1. J Clin Microbiol [Internet]. 2014;52(9):3509–10. Available from:; Shibata I, Tsuda T, Mori M, Ono M, Sueyoshi M, Uruno K. Isolation of porcine epidemic diarrhea virus in porcine cell cultures and experimental infection of pigs of different ages. Vet Microbiol [Internet]. 2000;72(3–4):173–82. Available from:; Wang H, Xia X, Liu Z, Liu Y, Wang S, Qi Z, et al. Outbreak of porcine epidemic diarrhea in piglets in Gansu province, China. Acta Sci Vet. 2013;41(1):1–4.; Crawford K, Lager K, Miller L, Opriessnig T, Gerber P, Hesse R. Evaluation of porcine epidemic diarrhea virus transmission and the immune response in growing pigs. Vet Res. 2015;1–9.; Goyal. Enviromental stability of PEDv. 2013;1–8. Available from:; Yang D, Leibowitz JL. The structure and functions of coronavirus genomic 3’ and 5’ ends. Virus Res [Internet]. 2015;206:120–33. Available from:; Harris H. Porcine Epidemic Diarrhea. In: Corp. S and D, editor. The Merck Veterinary Manual [Internet]. Kenilworth, N.J., U.S.A.; 2012. Available from:; N.A. Kamau , J.Y. Park , J.E. Park , B.H. Hyun , D.K. Yang JYS and HJS. Susceptibility of Mice to Porcine Epidemic Diarrhea Virus. J Anim Vet Adv. 2010;9(24):3114–6.; Yoon KJ, Dipl A. Porcine epidemic diarrhea : Pathogenesis and diagnostics. 2013;603–4.; Rui-Qin Sun, Ru-Jian Cai, Ya-Qiang Chen, Peng-Shuai Liang, De-Kun Chen and C-XS. Outbreak of Porcine Epidemic Diarrhea in Suckling Piglets, China. J Infect Dis [Internet]. 2012;18(1):161–3. Available from:; Pensaert MB, de Bouck P. A new coronavirus-like particle associated with diarrhea in swine. Arch Virol [Internet]. 1978 Jan [cited 2015 Nov 19];58(3):243–7. Available from:; Van Reeth K, Pensaert M. Prevalence of infections with enzootic respiratory and enteric viruses in feeder pigs entering fattening herds. Vet Rec [Internet]. 1994 Dec 17 [cited 2015 Nov 19];135(25):594–7. Available from:; Jung K, Saif LJ. Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. Vet J [Internet]. 2015;204(2):134–43. Available from:; Song D, Moon H, Kang B. Porcine epidemic diarrhea: a review of current epidemiology and available vaccines. Clin Exp Vaccine Res [Internet]. 2015;4(2):166–76. Available from: /pmc/articles/PMC4524901/?report=abstract; Rodak L, Valicek L, Smid B, Nevorankova Z. An ELISA optimized for porcine epidemic diarrhoea virus detection in faeces. Vet Microbiol. 2005;105(1):9–17.; Martelli P1, Lavazza A, Nigrelli AD, Merialdi G, Alborali LG PM. Epidemic of diarrhoea caused by porcine epidemic diarrhoea virus in Italy. Vet Rec. 2008;162(10):307–10.; Li W, Li H, Liu Y, Pan Y, Deng F, Song Y, et al. New variants of porcine epidemic diarrhea virus, China, 2011. Emerg Infect Dis. 2012;18(8):1350–3.; Huang YW, Dickerman AW, Pineyro P, Li L, Fang L, Kiehne R, et al. Origin, evolution, and genotyping of emergent porcine epidemic diarrhea virus strains in the United States. MBio. 2013;4(5):e00737-13.; Alvarez J, Goede D, Morrison R, Perez A. Spatial and temporal epidemiology of porcine epidemic diarrhea (PED) in the Midwest and Southeast regions of the United States. Prev Vet Med [Internet]. 2016 Jan 1 [cited 2016 Jan 29];123:155–60. Available from:; USDA. Swine Enteric Coronavirus Disease (SECD) Situation Report - Dec 31 2015 [Internet]. 2015. Available from:; OIE -WAHID. Diarrea Epidemica Porcina - Canada [Internet]. 2014. Available from:; North American Meat Institute - NAMI. The United States Meat Industry at a Glance [Internet]. 2013. Available from:; Economica A. Estadísticas Económicas semanales - Semana 08 de 2015 [Internet]. Bogotá DC; 2015. Available from:; Pensaert MB y YSG. Porcine Epidemic Diarrhea. In: Straw BE ZJDS y TD, editor. Diseases of Swine. 9th ed. Iowa USA: Blackwell Publishing; 2006. p. 367–72.; Saif LJ y SK. Transmissible gastroenteritis and porcine respiratory coronavirus. In: Straw BE, Zimmerman JJ DS y T, editor. Diseases of Swine. 9th ed. Iowa USA: Blackwell Publishing; 2006. p. 489–516.; Collins PJ, Martella V, O’Shea H. Detection and characterization of group C rotaviruses in asymptomatic piglets in Ireland. J Clin Microbiol. 2008;46(9):2973–9.; Jarvis Matthew C, Ham Ching Lam RA and MDG. Complete Genome Sequence of Porcine Epidemic Diarrhea Virus Strain COL / Cundinamarca / 2014 from Colombia. 2016;4(2):42304.; Asociación Colombiana de Porcicultores FNP. Avance de situación de la diarrea epidémica porcina en colombia. Bol Epidemiol No 1 [Internet]. 2016;(1):8. Available from:; Area de Erradicación de PPC Asoporcicultores/ FNP. Boletin Epidmeiologico No 6- avance de la situación de la Diarrea Epidemica Porcina en Colombia [Internet]. Bogotá DC; 2015. Available from:; Geiger JO, Connor JF. Porcine Epidemic Diarrhea , Diagnosis , and Elimination. 2013;1–4.; Dee S, Clement T, Schelkopf A, Nerem J, Knudsen D, Christopher-Hennings J, et al. An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naive pigs following consumption via natural feeding behavior: proof of concept. BMC Vet Res. 2014;10:176.; Morrison B, Goede D. Epidemiology and economic impact of PED. 2013;605–12.; Morrison PIRB, Davies CP, Goede D. 13-216 : Epidemiologic investigation on propensity for lateral spread of PED virus. 2013; Available from:; O’Dea EB, Snelson H, Bansal S. Using heterogeneity in the population structure of U.S. swine farms to compare transmission models for porcine epidemic diarrhoea. Sci Rep [Internet]. 2016;6(August 2015):22248. Available from:; Alonso C, Goede DP, Morrison RB, Davies PR, Rovira A, Marthaler DG, et al. Evidence of infectivity of airborne porcine epidemic diarrhea virus and detection of airborne viral RNA at long distances from infected herds. Vet Res. 2014;45:73.; Rui-Qin Sun, Ru-Jian Cai, Ya-Qiang Chen, Peng-Shuai Liang, De-Kun Chen and C-XS. Outbreak of porcine epidemic diarrhea in suckling piglets, China. J Infect Dis [Internet]. 2012;1:161–3. Available from:; Thomas. Evaluation of time and temperature sufficient to inactivate porcine epidemic diarrhea virus in swine feces on metal surfaces. 234rd IPVS Congr [Internet]. 2014;1(Virology and Viral Diseases-Coronaviruses):249. Available from:; Thomas JT, Chen Q, Gauger PC, Gimenez-Lirola LG, Sinha A, Harmon KM, et al. Effect of Porcine Epidemic Diarrhea Virus Infectious Doses on Infection Outcomes in Naive Conventional Neonatal and Weaned Pigs. PLoS One. 2015;10(10):e0139266.; Lee DU, Kwon T, Je SH, Yoo SJ, Seo SW, Sunwoo SY, et al. Wild boars harboring porcine epidemic diarrhea virus (PEDV) may play an important role as a PEDV reservoir. Vet Microbiol [Internet]. 2016;192:90–4. Available from:; Truong QL, Seo TW, Yoon B-I, Kim H-C, Han JH, Hahn T-W. Prevalence of swine viral and bacterial pathogens in rodents and stray cats captured around pig farms in Korea. J Vet Med Sci [Internet]. 2013;75(12):1647–50. Available from:; FAO/OIE/WB. Good practices for biosecurity in the pig sector - Issues and options in developing and transition countries [Internet]. FAO Animal Production and Health Paper No. 169. 2010. 74 p. Available from:; PorkCheckOff. Guia para la salud del cerdo PEDV [Internet]. PEDV Recursos. Iowa USA; 2014. Available from:; Bowman AS, Nolting JM, Nelson SW, Bliss N, Stull JW, Wang Q, et al. Effects of disinfection on the molecular detection of porcine epidemic diarrhea virus. Vet Microbiol [Internet]. 2015;179(3–4):213–8. Available from:; Lee C. Porcine epidemic diarrhea virus : An emerging and re-emerging epizootic swine virus. Virol J [Internet]. 2015;(2015):1–16. Available from:; Kim YK, Lim S-I, Cho I-S, Cheong K-M, Lee E-J, Lee S-O, et al. A novel diagnostic approach to detecting porcine epidemic diarrhea virus: The lateral immunochromatography assay. J Virol Methods [Internet]. 2015;225:4–8. Available from:; Yu X, Shi L, Lv X, Yao W, Cao M, Yu H, et al. Development of a real-time reverse transcription loop-mediated isothermal amplification method for the rapid detection of porcine epidemic diarrhea virus. Virol J [Internet]. 2015;12:76. Available from:; Yuan W, Li Y, Li P, Song Q, Li L, Sun J. Development of a nanoparticle-assisted PCR assay for detection of porcine epidemic diarrhea virus. J Virol Methods [Internet]. 2015;220:18–20. Available from:; Miller LC, Crawford KK, Lager KM, Kellner SG, Brockmeier SL. Evaluation of two real-time polymerase chain reaction assays for Porcine epidemic diarrhea virus (PEDV) to assess PEDV transmission in growing pigs. J Vet Diagn Invest [Internet]. 2016;28(1):20–9. Available from:; Wang Z, Jiyuan Y, Su C, Xinyuan Q, Lijie T, Yijing L. Development of an antigen capture enzyme-linked immunosorbent assay for virus detection based on porcine epidemic diarrhea virus monoclonal antibodies. Viral Immunol [Internet]. 2015;28(3):184–9. Available from:; Asociación Colombiana de Porcicultores FNP. Informe de los proyectos de Inversión desarrollados en el 2013 [Internet]. Bogotá DC; 2013. Available from:; ICA. RESOLUCION ICA 797 2014 “Por medio de la cual se declara en emergencia sanitaria el territorio nacional, por la ocurrencia de una enfermedad inusual en animales de la especie porcina”. [Internet]. Colombia: Instituto Colombiano Agropecuario- ICA; 2014 p. 1–3. Available from:; OIE. Glosario - Codigo sanitario para los animales terrestres [Internet]. Organizacion Mundial de Sanidad Animal - OIE; 2016. Available from:; The Center for Food Security and Public Health at Iowa State University. Desinfection -Characteristics of Selected Disinfectants [Internet]. Iowa USA; 2008. Available from:; Instituto Nacional de Investigaciones Forestales Agricolas y Pecuarias - INIFAP Antonio Morilla. Bioseguridad en granjas porcinas [Internet]. 2009. Available from:; Kim O, Chae C. Comparison of reverse transcription polymerase chain reaction, immunohistochemistry, and in situ hybridization for the detection of porcine epidemic diarrhea virus in pigs. Can J Vet Res. 2002;66(2):112–6.; J L, P G, K H, J Z, J C, P Y, et al. Role of transportation in spread of porcine epidemic diarrhea virus infection, United States. 2014;20(5):2005–8.; Sasaki Y, Alvarez J, Sekiguchi S, Sueyoshi M, Otake S, Perez A. Epidemiological factors associated to spread of porcine epidemic diarrhea in Japan. Prev Vet Med. 2016;123:161–7.; Alonso C, Raynor PC, Davies PR, Torremorell M. Concentration, Size Distribution, and Infectivity of Airborne Particles Carrying Swine Viruses. PLoS One [Internet]. 2015;10(8):e0135675. Available from:; Sasaki Y, Alvarez J, Sekiguchi S, Sueyoshi M, Otake S, Perez A. Epidemiological factors associated to spread of porcine epidemic diarrhea in Japan. Prev Vet Med [Internet]. 2016 Jan 1 [cited 2016 Jan 31];123:161–7. Available from: |
بيانات النشر: | Universidad del Rosario Maestría en Epidemiología Facultad de medicina 2017-01-16 2017-02-06T14:21:16Z |
نوع الوثيقة: | Electronic Resource |
مستخلص: | Introducción: La diarrea epidémica porcina es una enfermedad infecciosa, que ataca principalmente a los lechones neonatos, con morbilidad del 80 al 100% y mortalidad del 50 al 90%. La forma más rápida de propagación del virus (PEDv) es el transporte de porcinos. Esta enfermedad ingresó a Colombia en el 2014 afectando la producción nacional sin que se conociera el comportamiento epidemiológico en el país. Previamente se había reportado a nivel mundial que la forma más rápida de propagación del virus (PEDv) es el transporte de porcinos. Objetivo: Determinar la prevalencia del PEDv y los factores asociados al transporte de cerdos a plantas de beneficio. Métodos: El diseño del estudio es de corte transversal, en una muestra de 518 camiones de transporte porcino en las 32 plantas legales autorizados en 2014 por el Instituto Nacional de Vigilancia de Medicamentos y Alimentos (INVIMA) en el país, con afijación proporcional por número de ingresos de vehículos a planta. Se realizó un muestreo en los camiones a la entrada y salida de la planta de beneficio los cuales fueron analizadas por RT-PCR y se aplicó encuesta a los conductores de los camiones. Resultados: La prevalencia de PEDv al ingreso de planta fue del 71,8% (IC 95% 70,8–72,8) vs. 70,5% (IC 95% 69,5–71,5) a la salida, p=0.375. Factores asociados con PEDv en camiones: Tipo de planta nacional (OR 15,95, IC 95% 4,91–51,85) y planta nacional – exportación (OR 9,02, IC 95% 2,20–36,91), zona de mayor sacrificio (OR 9,05, IC 95% 2,97–27,63) y uso de los camiones tanto para el transporte de cerdos como otros productos (OR 3,75 IC 95% 1,55-9,08) y visita a plantas de alimentos concentrados (OR 13,56 IC 95% 4,17–44,12). Factores que reducen la posibilidad de contaminación de PEDv en camiones: Lavado semanal o diario, uso de desinfectantes y uso exclusivo para transporte porcino. Discusión: Los resultados del estudio, con prevalencia del 71,8% de PEDv en los camiones evidencian que las medidas de control en el transporte de p Introduction: Epidemic porcine diarrhea is an infectious disease, which mainly attacks neonate piglets, with morbidity from 80 to 100% and mortality from 50 to 90%. The most rapid form of virus spread (PEDV) is the transport of swine. This disease got it to Colombia in 2014 affecting the national production without knowing the epidemiological behavior in the country. It has been previously reported worldwide that the fastest form of virus spread (PEDV) is the swine transport. Objective: Determine the prevalence of PEDV and factors associated with the transport of pigs to benefit plants. Methods: The research's design is a cross-sectional study, with a sample of 518 pig transport trucks in the 32 main slaughterhouses authorized in 2014 by the National Drug and Food Surveillance Institute (INVIMA) in the country, with proportional allocation according to the number of vehicle entrances to the plants. Sampling was carried out in the trucks at the entry and exit of the slaughterhouses, which were analyzed by RT-PCR and a survey applied to truck drivers. Results: The prevalence of PEDv at the ingress to plant was of 71,8% (CI 95% 70,8 - 72,8) vs. 70,5% (CI 95% 69,5 - 71,5) to the exit, p=0,375. Were evidenced as associated factors to the PEDv contamination of the trucks: the type of national slaughterhouse (OR 15,9, CI 95% 4,9 - 51,85) and national - exportation slaughterhouse (OR 9,0 CI 95%: 2,20 - 36,91), the zone of highest slaughter (OR 9,05 CI 95% 2,9 - 27,63) and the non-exclusive use of vehicle to swine transport (OR 3,75, CI 95%: 1,55 - 9,08) and the visit to plants of food concentrates (OR 13,5 CI 95%: 4,1 - 44,12). Were identified as factors that reduce the possibility of PEDv contamination the weekly or daily washing, use of disinfectants on the vehicle and it's the exclusive use to pig transport. Discussion: The results of the study, with a prevalence of 71.8% of PEDv in the trucks, show that the control measures in the pig transport process in Colombia prese Asociación Colombiana de Porcicultores/Fondo Nacional de la Porcicultura Ceniporcino |
مصطلحات الفهرس: | Virus de la Diarrea Epidémica Porcina, PEDv, Reacción en Cadena de la Polimerasa, Porcinos, Mataderos, Prevalencia, Epidemiología, 614.4, Porcine Epidemic Virus, PEDv, Polymerase Chain Reaction, PCR, Swine, Slaughterhouses, Prevalence, Epidemiology, Salud publica, Virus de la diarrea epidémica porcina, info:eu-repo/semantics/masterThesis, info:eu-repo/semantics/acceptedVersion |
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الاتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by-nc-nd/2.5/co info:eu-repo/semantics/openAccess |
ملاحظة: | application/pdf Spanish |
Other Numbers: | COUDR oai:repository.urosario.edu.co:10336/12856 984510119 |
المصدر المساهم: | UNIVERSIDAD DEL ROSARIO From OAIster®, provided by the OCLC Cooperative. |
رقم الانضمام: | edsoai.ocn984510119 |
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