Electronic Resource
MATERNAL VITAMIN D STATUS DURING PREGNANCY AS A PREDICTOR OF OFFSPRING BONE MASS AT THREE YEARS OF AGE
| العنوان: | MATERNAL VITAMIN D STATUS DURING PREGNANCY AS A PREDICTOR OF OFFSPRING BONE MASS AT THREE YEARS OF AGE |
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| المؤلفون: | Ng, Melody, Atkinson, S.A., Medical Sciences |
| بيانات النشر: | 2011-10; 2011-09-28 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Emerging evidence indicates that in utero exposure to vitamin D metabolites may influence fetal and neonatal bone development. Bone accretion in prenatal and early postnatal life may impact peak bone mass achieved in early adolescence; and peak bone mass is a well-established predictor of osteoporosis risk in later life. Hypothesis: We hypothesized that offspring of mothers with higher serum vitamin D status during pregnancy will have higher whole body BMC z-score and bone size at 3 years of age, after adjustment for confounders. Methods: In a prospective, longitudinal study, 372 mothers with singleton birth were recruited during pregnancy, and maternal blood samples were obtained during the third trimester. Child bone outcome measures at 3 years of age included: whole body BMC, femoral and humeral lengths by DXA. We controlled for other relevant factors such as maternal nutrition, pre-pregnancy BMI, physical activity during pregnancy, maternal BMD, as well as the child’s nutrition at 6 months and 3 years, and the child’s physical activity. Results & Discussion: Maternal vitamin D status during pregnancy did not predict whole body BMC z-score of the child at 3 years of age. Over 92% of Canadian women in our sample were vitamin D sufficient with mean intakes of 435 IU/day from food and supplements and mean serum 25OHD of 111.2 nM. Further, data indicate a potential negative effect on offspring bone size at maternal serum 25OHD concentrations that exceed the upper limit suggested by the most recent DRI report (>125 nM), at which adverse health effects may occur. Our findings may differ from previous studies in the United Kingdom, India and Finland that found a positive relationship between maternal vitamin D status and child bone outcomes due to the high frequency of our mothers that had optimal vitamin D status. In addition, we adjusted for most of the key covariates that were not adjusted for in previous studies Master of Science (MSc) |
| مصطلحات الفهرس: | vitamin D, bone, pregnancy, developmental origins of health and disease, nutrition, maternal determinants of offspring health, Medicine and Health Sciences, thesis |
| URL: | |
| الاتاحة: | Open access content. Open access content |
| Other Numbers: | MUH oai:macsphere.mcmaster.ca:11375/11353 opendissertations/6326 7378 2262799 957448104 |
| المصدر المساهم: | MCMASTER UNIV From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn957448104 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |