Electronic Resource
Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
| العنوان: | Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation |
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| المؤلفون: | University of Helsinki, Clinicum, Gusev, Alexander, Shi, Huwenbo, Kichaev, Gleb, Pomerantz, Mark, Li, Fugen, Long, Henry W., Ingles, Sue A., Kittles, Rick A., Strom, Sara S., Rybicki, Benjamin A., Nemesure, Barbara, Isaacs, William B., Zheng, Wei, Pettaway, Curtis A., Yeboah, Edward D., Tettey, Yao, Biritwum, Richard B., Adjei, Andrew A., Tay, Evelyn, Truelove, Ann, Niwa, Shelley, Chokkalingam, Anand P., John, Esther M., Murphy, Adam B., Signorello, Lisa B., Carpten, John, Leske, M. Cristina, Wu, Suh-Yuh, Hennis, Anslem J. M., Neslund-Dudas, Christine, Hsing, Ann W., Chu, Lisa, Goodman, Phyllis J., Klein, Eric A., Witte, John S., Casey, Graham, Kaggwa, Sam, Cook, Michael B., Stram, Daniel O., Blot, William J., Eeles, Rosalind A., Easton, Douglas, Kote-Jarai, ZSofia, Al Olama, Ali Amin, Benlloch, Sara, Muir, Kenneth, Giles, Graham G., Southey, Melissa C., Fitzgerald, Liesel M., Gronberg, Henrik, Wiklund, Fredrik, Aly, Markus, Henderson, Brian E., Schleutker, Johanna, Wahlfors, Tiina, Tammela, Teuvo L. J., Nordestgaard, Borge G., Key, Tim J., Travis, Ruth C., Neal, David E., Donovan, Jenny L., Hamdy, Freddie C., Pharoah, Paul, Pashayan, Nora, Khaw, Kay-Tee, Stanford, Janet L., Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Maier, Christiane, Vogel, Walther, Luedeke, Manuel, Herkommer, Kathleen, Kibel, Adam S., Cybulski, Cezary, Wokolorczyk, Dominika, Kluzniak, Wojciech, Cannon-Albright, Lisa, Teerlink, Craig, Brenner, Hermann, Dieffenbach, Aida K., Arndt, Volker, Park, Jong Y., Sellers, Thomas A., Lin, Hui-Yi, Slavov, Chavdar, Kaneva, Radka, Mitev, Vanio, Batra, Jyotsna, Spurdle, Amanda, Clements, Judith A., Teixeira, Manuel R., Pandha, Hardev, Michael, Agnieszka, Paulo, Paula, Maia, Sofia, Kierzek, Andrzej, Conti, David V., Albanes, Demetrius, Berg, Christine, Berndt, Sonja I., Campa, Daniele, Crawford, E. David, Diver, W. Ryan, Gapstur, Susan M., Gaziano, J. Michael, Giovannucci, Edward, Hoover, Robert, Hunter, David J., Johansson, Mattias, Kraft, Peter, Le Marchand, Loic, Lindstrom, Sara, Navarro, Carmen, Overvad, Kim, Riboli, Elio, Siddiq, Afshan, Stevens, Victoria L., Trichopoulos, Dimitrios, Vineis, Paolo, Yeager, Meredith, Trynka, Gosia, Raychaudhuri, Soumya, Schumacher, Frederick R., Price, Alkes L., Freedman, Matthew L., Haiman, Christopher A., Pasaniuc, Bogdan, Cook, Margaret, Guy, Michelle, Govindasami, Koveela, Leongamornlert, Daniel, Sawyer, Emma J., Wilkinson, Rosemary, Saunders, Edward J., Tymrakiewicz, Malgorzata, Dadaev, Tokhir, Morgan, Angela, Fisher, Cyril, Hazel, Steve, Livni, Naomi, Lophatananon, Artitaya, Pedersen, John, Hopper, John L., Adolfson, Jan, Stattin, Paer, Johansson, Jan-Erik, Cavalli-Bjoerkman, Carin, Karlsson, Ami, Broms, Michael, Auvinen, Anssi, Kujala, Paula, Maattanen, Liisa, Murtola, Teemu, Taari, Kimmo, Weischer, Maren, Nielsen, Sune F., Klarskov, Peter, Roder, Andreas, Iversen, Peter, Wallinder, Hans, Gustafsson, Sven, Cox, Angela, Brown, Paul, George, Anne, Marsden, Gemma, Lane, Athene, Davis, Michael, Tillmans, Lori, Riska, Shaun, Wang, Liang, Rinckleb, Antje, Lubiski, Jan, Stegmaier, Christa, Pow-Sang, Julio, Park, Hyun, Radlein, Selina, Rincon, Maria, Haley, James, Zachariah, Babu, Kachakova, Darina, Popov, Elenko, Mitkova, Atanaska, Vlahova, Aleksandrina, Dikov, Tihomir, Christova, Svetlana, Heathcote, Peter, Wood, Glenn, Malone, Greg, Saunders, Pamela, Eckert, Allison, Yeadon, Trina, Kerr, Kris, Collins, Angus, Turner, Megan, Srinivasan, Srilakshmi, Kedda, Mary-Anne, Alexander, Kimberly, Omara, Tracy, Wu, Huihai, Henrique, Rui, Pinto, Pedro, Santos, Joana, Barros-Silva, Joao, PRACTICAL Consortium |
| المصدر: | Gusev , A , Shi , H , Kichaev , G , Pomerantz , M , Li , F , Long , H W , Ingles , S A , Kittles , R A , Strom , S S , Rybicki , B A , Nemesure , B , Isaacs , W B , Zheng , W , Pettaway , C A , Yeboah , E D , Tettey , Y , Biritwum , R B , Adjei , A A , Tay , E , Truelove , A , Niwa , S , Chokkalingam , A P , John , E M , Murphy , A B , Signorello , L B , Carpten , J , Leske , M C , Wu , S-Y , Hennis , A J M , Neslund-Dudas , C , Hsing , A W , Chu , L , Goodman , P J , Klein , E A , Witte , J S , Casey , G , Kaggwa , S , Cook , M B , Stram , D O , Blot , W J , Eeles , R A , Easton , D , Kote-Jarai , Z S , Al Olama , A A , Benlloch , S , Muir , K , Giles , G G , Southey , M C , Fitzgerald , L M , Gronberg , H , Wiklund , F , Aly , M , Henderson , B E , Schleutker , J , Wahlfors , T , Tammela , T L J , Nordestgaard , B G , Key , T J , Travis , R C , Neal , D E , Donovan , J L , Hamdy , F C , Pharoah , P , Pashayan , N , Khaw , K-T , Stanford , J L , Thibodeau , S N , McDonnell , S K , Schaid , D J , Maier , C , Vogel , W , Luedeke , M , Herkommer , K , Kibel , A S , Cybulski , C , Wokolorczyk , D , Kluzniak , W , Cannon-Albright , L , Teerlink , C , Brenner , H , Dieffenbach , A K , Arndt , V , Park , J Y , Sellers , T A , Lin , H-Y , Slavov , C , Kaneva , R , Mitev , V , Batra , J , Spurdle , A , Clements , J A , Teixeira , M R , Pandha , H , Michael , A , Paulo , P , Maia , S , Kierzek , A , Conti , D V , Albanes , D , Berg , C , Berndt , S I , Campa , D , Crawford , E D , Diver , W R , Gapstur , S M , Gaziano , J M , Giovannucci , E , Hoover , R , Hunter , D J , Johansson , M , Kraft , P , Le Marchand , L , Lindstrom , S , Navarro , C , Overvad , K , Riboli , E , Siddiq , A , Stevens , V L , Trichopoulos , D , Vineis , P , Yeager , M , Trynka , G , Raychaudhuri , S , Schumacher , F R , Price , A L , Freedman , M L , Haiman , C A , Pasaniuc , B , Cook , M , Guy , M , Govindasami , K , Leongamornlert , D , Sawyer , E J , Wilkinson , R , Saunders , E J , Tymrakiewicz , |
| بيانات النشر: | Nature Publishing Group 2016-04 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Although genome-wide association studies have identified over 100 risk loci that explain similar to 33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa. |
| مصطلحات الفهرس: | GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, COMMON DISEASES, COMPLEX TRAITS, RISK, SNPS, ENHANCERS, ELEMENTS, PITFALLS, ENCODE, 3122 Cancers, 3126 Surgery, anesthesiology, intensive care, radiology, 3111 Biomedicine, A1 Refereed journal article, info:eu-repo/semantics/article, info:eu-repo/semantics/publishedVersion |
| URL: | Nature Communications |
| الاتاحة: | Open access content. Open access content |
| ملاحظة: | 13 English |
| Other Numbers: | FITDS oai:helda.helsinki.fi:10138/161395 2041-1723 948970147 |
| المصدر المساهم: | TERKKO DOC SPACE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn948970147 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |