Electronic Resource
Cell dynamics and immune response to BLV infection: a unifying model
| العنوان: | Cell dynamics and immune response to BLV infection: a unifying model |
|---|---|
| المؤلفون: | Florins, Arnaud, Gillet, Nicolas, Asquith, Becca, Boxus, Mathieu, Burteau, Catherine, Twizere, Jean-Claude, Urbain, Patrice, Vandermeers, Fabian, Debacq, Christophe, Sanchez-Alcaraz, Maria Teresa, Schwartz-Cornil, Isabelle, Kerkhofs, Pierre R.M.A.M., Jean, Genèvieve, Thewis, André, Hay, Jack, Mortreux, Franck, Wattel, Eric, Reichert, Michal, Burny, Arsène, Kettmann, Richard, Bangham, Charles, Willems, Lucas |
| المصدر: | Frontiers in bioscience :a journal and virtual library, 12 (4 |
| بيانات النشر: | 2007 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Bovine Leukemia virus (BLV) is the natural etiological agent of a lymphoproliferative disease in cattle. BLV can also be transmitted experimentally to a related ruminant species, sheep, in which the pathogenesis is more acute. Although both susceptible species develop a strong anti-viral immune response, the virus persists indefinitely throughout life, apparently at a transcriptionally silent stage, at least in a proportion of infected cells. Soon after infection, these humoral and cytotoxic activities very efficiently abolish the viral replicative cycle, permitting only mitotic expansion of provirus-carrying cells. Short term cultures of these infected cells initially indicated that viral expression protects against spontaneous apoptosis, suggesting that leukemia is a process of accumulation of long-lived cells. This conclusion was recently reconsidered following in vivo dynamic studies based on perfusions of nucleoside (bromodeoxyuridine) or fluorescent protein markers (CFSE). In sheep, the turnover rate of infected cells is increased, suggesting that a permanent clearance process is exerted by the immune system. Lymphocyte trafficking from and to the secondary lymphoid organs is a key component in the maintenance of cell homeostasis. The net outcome of the immune selective pressure is that only cells in which the virus is transcriptionally silenced survive and accumulate, ultimately leading to lymphocytosis. Activation of viral and/or cellular expression in this silent reservoir with deacetylase inhibitors causes the collapse of the proviral loads. In other words, modulation of viral expression appears to be curative in lymphocytic sheep, an approach that might also be efficient in patients infected with the related Human T-lymphotropic virus type 1. In summary, a dynamic interplay between BLV and the host immune response modulates a complex equilibrium between (i) viral expression driving (or) favoring proliferation and (ii) viral silencing preventing apoptosis. info:eu-repo/semantics/published |
| مصطلحات الفهرس: | Sciences bio-médicales et agricoles, Animals, Antibody Formation, Apoptosis, Cattle, Enzootic Bovine Leukosis -- drug therapy -- immunology -- virology, Leukemia Virus, Bovine -- genetics -- pathogenicity -- physiology, Models, Immunological, Sheep, Sheep Diseases -- virology, T-Lymphocytes, Cytotoxic -- immunology, Transcription, Genetic, Virus Replication, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article |
| URL: | |
| الاتاحة: | Open access content. Open access content 1 full-text file(s): info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | 1 full-text file(s): application/pdf English |
| Other Numbers: | EQY oai:dipot.ulb.ac.be:2013/226323 uri/info:doi/10.2741/2165 uri/info:pii/2165 uri/info:pmid/17127399 uri/info:scp/34249792077 local/VX-005943 948063737 |
| المصدر المساهم: | UNIVERSITE LIBRE DE BRUXELLES From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn948063737 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |