Electronic Resource
A human homolog of the yeast nucleotide excision repair gene MMS19 interacts with transcription repair factor TFIIH through the XPB and XPD helicases.
| العنوان: | A human homolog of the yeast nucleotide excision repair gene MMS19 interacts with transcription repair factor TFIIH through the XPB and XPD helicases. |
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| المؤلفون: | Seroz, T., Winkler, G.S. (Sebastiaan), Auriol, J., Verhage, R.A., Vermeulen, W. (Wim), Smit, B. (Bep), Brouwer, J. (Jaap), Eker, A.P.M. (André), Weeda, G. (Geert), Egly, J-M. (Jean-Marc), Hoeijmakers, J.H.J. (Jan) |
| بيانات النشر: | 2000-01-01 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Nucleotide excision repair (NER) removes UV-induced photoproducts and numerous other DNA lesions in a highly conserved 'cut-and-paste' reaction that involves approximately 25 core components. In addition, several other proteins have been identified which are dispensable for NER in vitro but have an undefined role in vivo and may act at the interface of NER and other cellular processes. An intriguing example is the Saccharomyces cerevisiae Mms19 protein that has an unknown dual function in NER and RNA polymerase II transcription. Here we report the cloning and characterization of a human homolog, designated hMMS19, that encodes a 1030 amino acid protein with 26% identity and 51% similarity to S.cerevisiae Mms19p and with a strikingly similar size. The expression profile and nuclear location are consistent with a repair function. Co-immunoprecipitation experiments revealed that hMMS19 directly interacts with |
| مصطلحات الفهرس: | Saccharomyces cerevisiae Proteins, Transcription Factors, TFII, 0 (DNA, Complementary), 0 (DNA-Binding Proteins), 0 (Fungal Proteins), 0 (MET18 protein, S cerevisiae), 0 (MMS19L protein, human), 0 (Proteins), 0 (RNA, Messenger), 0 (Saccharomyces cerevisiae Proteins), 0 (Taf6 protein, Drosophila), 0 (Transcription Factors), 0 (Transcription Factors, TFII), 130067-74-2 (ERCC-2 protein), 146045-44-5 (XPBC-ERCC-3 protein), 148710-81-0 (transcription factor TFIIH), Amino Acid Sequence, Animals, Blotting, Northern, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 10/genetics, Cloning, Molecular, DNA Helicases/*metabolism, DNA Repair/*genetics, DNA, Complementary/chemistry/genetics, DNA-Binding Proteins/metabolism, EC 5.99.- (DNA Helicases), Female, Fungal Proteins/genetics, Gene Expression, Gene Expression Regulation, Developmental, Hela Cells, Human, In Situ Hybridization, Fluorescence, Male, Molecular Sequence Data, Phylogeny, Protein Binding, Proteins/*genetics/metabolism, RNA, Messenger/genetics/metabolism, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Support, Non-U.S. Gov't, Tissue Distribution, Transcription Factors/*metabolism, info:eu-repo/semantics/article |
| DOI: | 10.1093.nar.28.22.4506 |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess |
| ملاحظة: | application/pdf Nucleic Acids Research vol. 28, pp. 4506-4513 English |
| Other Numbers: | QGQ oai:repub.eur.nl:3171 doi:10.1093/nar/28.22.4506 urn:hdl:1765/3171 929960266 |
| المصدر المساهم: | ERASMUS UNIVERSITEIT ROTTERDAM From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn929960266 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1093.nar.28.22.4506 |
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