Electronic Resource
Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice
| العنوان: | Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice |
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| المؤلفون: | Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland, Department of Periodontics and Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas, University of Rochester Eye Institute, University of Rochester, Rochester, New York, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, Rockville, Maryland ; Laboratory of Molecular Biology, NIDCD/NIH, 5 Research Court, Rm 2B34, Rockville, MD 20850, Hwang, Chan Ho, Guo, Dayong, Harris, Marie A., Howard, Omar, Mishina, Yuji, Gan, Lin, Harris, Stephen E., Wu, Doris K. |
| بيانات النشر: | Wiley-Liss, Inc. 2010-02-02T15:31:34Z WITHHELD_12_MONTHS 2010-02-02T15:31:34Z 2010-02 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | The mammalian organ of Corti of the inner ear is a highly sophisticated sensory end organ responsible for detecting sound. Noggin is a secreted glycoprotein, which antagonizes bone morphogenetic proteins 2 and 4 (Bmp2 and Bmp4). The lack of this antagonist causes increased rows of inner and outer hair cells in the organ of Corti. In mice, Bmp2 is expressed transiently in nascent cochlear hair cells. To investigate whether Noggin normally modulates the levels of Bmp2 for hair cell formation, we deleted Bmp2 in the cochlear hair cells using two cre strains, Foxg1 cre /+ and Gfi1 cre /+ . Bmp2 conditional knockout cochleae generated using these two cre strains show normal hair cells. Furthermore, Gfi1 cre /+ ; Bmp2 lox /??? mice are viable and have largely normal hearing. The combined results of Noggin and Bmp2 mutants suggest that Noggin is likely to regulate other Bmps in the cochlea such as Bmp4. Developmental Dynamics 239:505???513, 2010. Published 2010 Wiley-Liss, Inc. |
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| الاتاحة: | Open access content. Open access content IndexNoFollow |
| Other Numbers: | EYM oai:deepblue.lib.umich.edu:2027.42/64918 1058-8388 1097-0177 20063299 10.1002/dvdy.22200 Developmental Dynamics 894397661 |
| المصدر المساهم: | UNIV OF MICHIGAN LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn894397661 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |