Electronic Resource
Role of oxidative damage in toxicity of particulates
| العنوان: | Role of oxidative damage in toxicity of particulates |
|---|---|
| المؤلفون: | Møller, Peter, Jacobsen, Nicklas R, Folkmann, Janne K, Danielsen, Pernille H, Mikkelsen, Lone, Hemmingsen, Jette G, Vesterdal, Lise K, Forchhammer, Lykke, Wallin, Håkan, Loft, Steffen |
| المصدر: | Møller , P , Jacobsen , N R , Folkmann , J K , Danielsen , P H , Mikkelsen , L , Hemmingsen , J G , Vesterdal , L K , Forchhammer , L , Wallin , H & Loft , S 2010 , ' Role of oxidative damage in toxicity of particulates ' , Free Radical Research , vol. 44 , no. 1 , pp. 1-46 . |
| بيانات النشر: | 2010 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Udgivelsesdato: 2010-Jan Particulates are small particles of solid or liquid suspended in liquid or air. In vitro studies show that particles generate reactive oxygen species, deplete endogenous antioxidants, alter mitochondrial function and produce oxidative damage to lipids and DNA. Surface area, reactivity and chemical composition play important roles in the oxidative potential of particulates. Studies in animal models indicate that particles from combustion processes (generated by combustion of wood or diesel oil), silicate, titanium dioxide and nanoparticles (C60 fullerenes and carbon nanotubes) produce elevated levels of lipid peroxidation products and oxidatively damaged DNA. Biomonitoring studies in humans have shown associations between exposure to air pollution and wood smoke particulates and oxidative damage to DNA, deoxynucleotides and lipids measured in leukocytes, plasma, urine and/or exhaled breath. The results indicate that oxidative stress and elevated levels of oxidatively altered biomolecules are important intermediate endpoints that may be useful markers in hazard characterization of particulates. |
| مصطلحات الفهرس: | article |
| URL: | |
| الاتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| Other Numbers: | DAV oai:pure.atira.dk:publications/e18eed60-2694-11df-8ed1-000ea68e967b 842755913 |
| المصدر المساهم: | UNIV OF COPENHAGEN From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn842755913 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |