Electronic Resource
Application of Photosynthesis to Artificial Sight
| العنوان: | Application of Photosynthesis to Artificial Sight |
|---|---|
| المؤلفون: | OAK RIDGE NATIONAL LAB TN CHEMICAL TECHNOLOGY DIV, Greenbaum, B., Humayue, M. S., Kuritz, T., Lee, J. W., Sanders, C. A. |
| المصدر: | DTIC AND NTIS |
| بيانات النشر: | 2001-10-25 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Using the technique of Kelvin force microscopy, we have performed the first measurements of photovoltages from single photosynthetic reaction centers 1. The measured values, typically 1 V or more, are sufficiently large to trigger a neural response. The goal of this project is insertion of purified Photosystem I (PSI) reaction centers or other photoactive agents into retinal cells where they will restore photoreceptor function to people who suffer from age-related macular degeneration (AMD) or retinitis pigmentosa (RP), diseases that are the leading causes of blindness world-wide. Although the neural wiring from eye to brain is intact, these patients lack photoreceptor activity. It is the ultimate goal of this proposal to restore photoreceptor activity to these patients using PSI as the optical trigger. In principle, the approach should work. PSI is a robust integral membrane molecular photovoltaic device. Depending on orientation, it can depolarize or hyperpolarize the cell membrane with sufficient voltage to trigger an action potential. Papers from 23rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, October 25-28, 2001, held in Istanbul, Turkey. See also ADM001351 for entire conference on cd-rom., The original document contains color images. |
| مصطلحات الفهرس: | Anatomy and Physiology, Medicine and Medical Research, RETINA, PIGMENTS, BLINDNESS, PHOTOSYNTHESIS, MEASUREMENT, OPTICAL PROPERTIES, GLOBAL, MEMBRANES(BIOLOGY), BRAIN, WIRE, VOLTAGE, MICROSCOPY, RESPONSE, SIGHTS, NERVOUS SYSTEM, EYE, CELLS(BIOLOGY), INFLAMMATION, PHOTOVOLTAIC EFFECT, TRIGGER CIRCUITS, PHOTORECEPTORS., RETINITIS PIGMENTOSA, ARTIFICIAL SIGHT, RP(RETINITIS PIGMENTOSA), PSI(PHOTOSYSTEM I), AMD(AGE-RELATED MASCULAR DEGENERATION), Text |
| URL: | |
| الاتاحة: | Open access content. Open access content APPROVED FOR PUBLIC RELEASE |
| ملاحظة: | text/html English |
| Other Numbers: | DTICE ADA412552 834247785 |
| المصدر المساهم: | From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn834247785 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |