Electronic Resource
Mechanisms and Chemoprevention of Ovarian Carcinogenesis
| العنوان: | Mechanisms and Chemoprevention of Ovarian Carcinogenesis |
|---|---|
| المؤلفون: | FOX CHASE CANCER CENTER PHILADELPHIA PA, Cvetkovic, Dusica |
| المصدر: | DTIC |
| بيانات النشر: | 2009-02 |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Ovarian cancer is the most fatal gynecological malignancy. The understanding of the early molecular events leading to ovarian cancer is important for the development of strategies for early detection and prevention. We have demonstrated that DMBA induced mutagenesis in the rat ovary, combined with gonadotropin hormone-mediated enhanced mitogenesis of the ovarian surface epithelium, produces lesions ranging from preneoplastic, early neoplastic to advanced ovarian tumors, resembling human disease. The goal of this project was to use the DMBA-gonadotropin animal model to study molecular mechanisms underlying ovarian oncogenesis and to conduct a preclinical chemoprevention trial. The original specific aims of the study were: 1) Determine the molecular genetic mechanisms underlying ovarian oncogenesis in the rat DMBA/gonadotropin model of ovarian cancer; 2) Determine the efficacy of the COX-1 inhibitor SC-560 to prevent the appearance and/or progression of DMBA-induced ovarian lesions; and 3) Study the in vivo mechanisms of the putative chemopreventive action of COX-1 inhibition. However, due to change of Principal Investigator in the last year of the study, the original research plan has been modified. Since the animal protocol pertaining to this project has been closed and the proposed chemoprevention trial in rats has not been initiated, only aim 1 is being carried out. The original document contains color images. |
| مصطلحات الفهرس: | Biochemistry, Medicine and Medical Research, OVARIAN CANCER, EPITHELIUM, HORMONES, RESEARCH MANAGEMENT, ONCOGENESIS, MOLECULAR PROPERTIES, GENETICS, MITOSIS, MEDIATION, NEOPLASMS, GONADOTROPINS, MOLECULES, IN VIVO ANALYSIS, OVARIAN CARCINOGENESIS, ANIMAL MODELS AND CDNA MICROARRAYS, Text |
| URL: | |
| الاتاحة: | Open access content. Open access content Approved for public release; distribution is unlimited. |
| ملاحظة: | text/html English |
| Other Numbers: | DTICE ADA506004 832059723 |
| المصدر المساهم: | From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn832059723 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |