التفاصيل البيبلوغرافية
| العنوان: |
Kardiotoxicita protinádorových léčiv: Studium molekulárních mechanizmů a možností farmakologické kardioprotekce |
| Alternate Title: |
Cardiotoxicity of Antineoplastic Drugs: Study of the Molecular Mechanisms and the Possibilities of Pharmacological Cardioprotection |
| المؤلفون: |
Vávrová, Anna |
| Thesis Advisors: |
Šimůnek, Tomáš, Hrdina, Radomír, Jun, Daniel |
| سنة النشر: |
2013 |
| المجموعة: |
Czech ETDs |
| الوصف: |
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Mgr. Anna Vávrová Supervisor: Doc. PharmDr. Tomáš Šimůnek, Ph.D. Title of Doctoral Thesis: Cardiotoxicity of antineoplastic drugs: Study of the molecular mechanisms and the possibilities of pharmacological cardioprotection. Anthracyclines are amongst the most widely used antineoplastic agents. Nevertheless, their use is limited by the risk of cardiotoxicity. Dexrazoxane has been the only approved cardioprotectant against anthracycline cardiotoxicity so far. Despite half a century of research, the mechanisms of its cardioprotective ability as well as the mechanisms of anthracycline toxicity are elusive. In this study, we focused on the study of the molecular mechanisms of dexrazoxane cardioprotection. We did not prove the principal role of glutathione and related antioxidant enzymes in the pathogenesis of anthracycline cardiotoxicity both in the in vitro experiments and in vivo in the samples of left ventricles from the well-established model of chronic anthracycline cardiotoxicity in rabbits. Moreover, we found that in vitro dexrazoxane is able to protect the isolated neonatal rat cardiomyocytes against anthracycline-, but not hydrogen peroxide-induced damage. As dexrazoxane is also a... |
| Original Identifier: |
oai:invenio.nusl.cz:322199 |
| نوع الوثيقة: |
Doctoral Thesis |
| اللغة: |
Czech |
| الاتاحة: |
http://www.nusl.cz/ntk/nusl-322199 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: |
edsndl.nusl.cz.oai.invenio.nusl.cz.322199 |
| قاعدة البيانات: |
Networked Digital Library of Theses & Dissertations |