Dissertation/ Thesis
Relation between Fine Particles Exposure and Respiratory Inflammation Biomarkers
| العنوان: | Relation between Fine Particles Exposure and Respiratory Inflammation Biomarkers |
|---|---|
| Alternate Title: | 細懸浮微粒暴露與呼吸系統發炎生物標記之相關性研究 |
| المؤلفون: | Ma, Ling-Yu, 馬翎瑜 |
| Thesis Advisors: | Lai, Ching-Huang, Liou, Saou-Hsing, 賴錦皇, 劉紹興 |
| سنة النشر: | 2014 |
| المجموعة: | National Digital Library of Theses and Dissertations in Taiwan |
| الوصف: | 102 Numerous studies have shown that particulate matter is associated with respiratory system health effect. The different aerodynamic diameters of the particles and the different deposition locations in the respiratory system cause different harmful effects on human beings. Like PM2.5 is aerodynamic diameter≦2.5μg/m3 and the pollution can reach a large surface area. It is more prone to carrying a variety of toxic heavy metals and other chemicals in alveolar and bronchial ends. It can enhance antigen-presenting by Endocytosis of macrophages, or enter the blood circulation system by lung air exchange to reach the other organs and causing the damage of structure and function in the respiratory. This study aimed to assess the relationship between PM2.5 exposure and lung inflammation and lung function in healthy adults. For this longitudinal study, we recruited 82 subjects from 2 different areas (Area A [residential and commercial area] and Area B [industrial area]) in Taipei Metropolitan at baseline. We investigated pulmonary and inflammation markers and lung function. We used personal samplers to collect 24 hours PM2.5 exposure samples. Venous blood and urine samples were collected on the next day morning. And serum clara cell protein (CC16), nitric oxide inexhaled breath (FeNO) were measured as inflammation markers and lung function was measured as health effects. All of subjects were repeated measured after two months. Statistical Methods used Generalized linear model and Generalized estimating equation. We found FEV1/FVC% decreasing -0.73% as PM2.5 increasing 10μg/m3, while CC16 increasing 1.04% as PM2.5 increasing 10μg/m3. And people who exposed PM2.5 levels above 20 μg/m3 the lung function parameters (FVC%, PEF%) were lower than that of exposed PM2.5 under 20 μg/m3, CC16 would be higher compared to that of PM2.5 exposure under 20 μg/m3. In addition, after controlling for confounding factors, the first repeated follow-up, as PM2.5 increasing 10 μg/m3，CC16 increasing 24.04% and FVCdecreasing 10.33% compared with that of baseline. We conclude young healthy subjects exposed to PM2.5 can lead to lung function decreasing or lung inflammation. |
| Original Identifier: | 102NDMC0058030 |
| نوع الوثيقة: | 學位論文 ; thesis |
| وصف الملف: | 98 |
| الاتاحة: | http://ndltd.ncl.edu.tw/handle/61442550512849160283 |
| رقم الانضمام: | edsndl.TW.102NDMC0058030 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |