Dissertation/ Thesis
Synthesis and Characterization Micelles that Contain Free Amine Groups ─ Amphiphilic Poly (ε-caprolactone) ─ Chitooligosaccharide ─ Poly (ethylene glycol) copolymer and its applications in Drug Delivery
| العنوان: | Synthesis and Characterization Micelles that Contain Free Amine Groups ─ Amphiphilic Poly (ε-caprolactone) ─ Chitooligosaccharide ─ Poly (ethylene glycol) copolymer and its applications in Drug Delivery |
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| Alternate Title: | 具自由胺基微胞之合成與特性分析及於藥物釋放之應用─聚己內脂-幾丁寡醣-聚乙二醇雙性共聚合物 |
| المؤلفون: | Jean-Dean Yang, 楊政典 |
| Thesis Advisors: | Tze-Wen Chung, Jui-Hsiang Hsieh, 鍾次文, 謝瑞香 |
| سنة النشر: | 2004 |
| المجموعة: | National Digital Library of Theses and Dissertations in Taiwan |
| الوصف: | 92 A new biodegradable amphiphilic copolymers, Poly (□-caprolactone) — chitooligosaccharide — poly (ethylene glycol) (PCL-g-COS-g-PEG, PCP) which contains free amine groups of COS, were synthesized and characterized. The characteristics of the PCP copolymers were examined by 1H Nuclear magnetic resonance (1H NMR), Fourier-transform infrared spectrometry (FT-IR) for function group analysis and Gel permeation chromatography (GPC) for determining molecular weight. The PCP copolymers can self-assembly to form micelles at the critical micelle concentration (CMC) about 8×10-3—1.6×10-2 wt.% (80 ~ 160 mg/L), determined by measuring UV-VIS absorption spectra of DPH loaded PCP micelles. Moreover, the average diameter of PCP micelles were 68.5 nm measured by a dynamic light-scattering (DLS) analyzer. The morphology of micelles was observed by Transmission Electron Microscopy (TEM) with sizes ranged from 20 to 120 nm. After the PCP copolymer was grafted with RGD by photochemical technique based on phenyl azido chemistry. For comparing the targeting capability of micelles, the RGD grafted PCP micelles (RGD-PCP) and PCP micelles was used to target PC-12 cell in vitro study. The results showed that RGD-PCP micelles were faster targeting capability than PCP micelles, and the free amine group of PCP micelles could be further crosslinked using a natural crosslinker, such as genipin, to improve the stability of the micelles. The new synthesized PCP copolymers and micelles containing amine groups can be further applied by chemical modification for drug delivery. |
| Original Identifier: | 092CYCU5530005 |
| نوع الوثيقة: | 學位論文 ; thesis |
| وصف الملف: | 108 |
| الاتاحة: | http://ndltd.ncl.edu.tw/handle/80473239492271763562 |
| رقم الانضمام: | edsndl.TW.092CYCU5530005 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |