Dissertation/ Thesis
Ferroptosis as a Lytic Form of Cell Death in Pancreatic Ductal Adenocarcinoma Cell Lines
| العنوان: | Ferroptosis as a Lytic Form of Cell Death in Pancreatic Ductal Adenocarcinoma Cell Lines |
|---|---|
| المؤلفون: | Taylor, Natalie M. |
| بيانات النشر: | Case Western Reserve University School of Graduate Studies / OhioLINK, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | Ohiolink ETDs |
| Original Material: | http://rave.ohiolink.edu/etdc/view?acc_num=case1674847422607912 |
| مصطلحات موضوعية: | Physiology, Cellular Biology, ferroptosis, pancreatic ductal adenocarcinoma, PDAC, pancreatic cancer, Ninjurin-1, MIA PaCa-2, PANC-1 |
| الوصف: | Pancreatic cancer is especially deadly due to challenges in treatment contributing to avery low survival rate of less than 5% in 5 years for patients with pancreatic ductaladenocarcinoma. Ferroptosis is a form of iron-induced cell death initiated primarily byphospholipid peroxidation. Harnessing ferroptosis may be a valuable tool to managechemoresistance in patients with pancreatic cancer. Several mechanisms of death viaferroptosis have been proposed, including the possibility that plasma membranerupture plays a role. We hypothesized, first, that ferroptosis is a lytic form of cell death,and second that differences in survival of cells treated with initiators of ferroptosis maybe mediated by differential expression or activation of Ninjurin-1. Through ourexperiments, we found that PANC-1 cells die more readily in response to initiators offerroptosis than MIA PaCa-2, and we determined that ferroptosis is a lytic form of celldeath. |
| Original Identifier: | oai:etd.ohiolink.edu:case1674847422607912 |
| نوع الوثيقة: | Text |
| اللغة: | English |
| الاتاحة: | http://rave.ohiolink.edu/etdc/view?acc_num=case1674847422607912 |
| Rights: | unrestricted This thesis or dissertation is protected by copyright: all rights reserved. It may not be copied or redistributed beyond the terms of applicable copyright laws. |
| رقم الانضمام: | edsndl.OhioLink.oai.etd.ohiolink.edu.case1674847422607912 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |