Academic Journal
Effect of concomitant Renal DeNervation and cardiac ablation on Atrial Fibrillation recurrence: RDN+AF study
| العنوان: | Effect of concomitant Renal DeNervation and cardiac ablation on Atrial Fibrillation recurrence: RDN+AF study |
|---|---|
| المؤلفون: | Kirstein, Bettina, Tomala, Jakub, Mayer, Julia, Ulbrich, Stefan, Wagner, Michael, Pu, Liying, Piorkowski, Judith, Hankel, Anastasia, Huo, Yan, Gaspar, Thomas, Richter, Utz, Hindricks, Gerhard, Piorkowski, Christopher |
| Publication Status: | publishedVersion |
| سنة النشر: | 2024 |
| المجموعة: | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Original Material: | urn:nbn:de:bsz:14-qucosa2-896259 |
| مصطلحات موضوعية: | ablation, arterial hypertension, atrial fibrillation, pulmonary vein isolation, renal denervation, Ablation, arterielle Hypertonie, Vorhofflimmern, Pulmonalvenenisolation, renale Denervierung, info:eu-repo/classification/ddc/610, ddc:610 |
| الوصف: | Background: Renal denervation (RDN) can reduce cardiac sympathetic activity maintained by arterial hypertension (aHT). Its potential antiarrhythmic effect on rhythm outcome in patients with multi-drug resistant aHT undergoing catheter ablation for atrial fibrillation (AF) is unclear. Methods: The RDN+AF study was a prospective, randomized, two-center trial. Patients with paroxysmal or persistent AF and uncontrolled aHT (mean systolic 24-h ambulatory BP > 135 mmHg) despite taking at least three antihypertensive drugs were enrolled. Patients were 1:2 randomized to either RDN+AF ablation or AF-only ablation. Primary endpoint was freedom from any AF episode > 2 min at 12 months assessed by implantable loop recorder (ILR) or 7d-holter electrocardiogram. Secondary endpoints included rhythm outcome at 24 months, blood pressure control, periprocedural complications, and renovascular safety. Results: The study randomized 61 patients (mean age 65 ± 9 years, 53% men). At 12 months, RDN+AF patients tended to have a greater decrease in ambulatory BPs but did not reach statistical significance. No differences in rhythm outcome were observed. Freedom from AF recurrence in the RDN+AF and AF-only group measured 61% versus 53% p = .622 at 12 months and 39% versus 47% p = .927 at 24 months, respectively. Periprocedural complications occurred in 9/61 patients (15%). No patient died. Conclusion: Among patients with multidrug-resistant aHT and paroxysmal or persistent AF, concomitant RDN+AF ablation was not associated with better blood pressure control or rhythm outcome in comparison to AF-only ablation and medical therapy. |
| Original Identifier: | oai:qucosa:de:qucosa:89625 |
| نوع الوثيقة: | Article |
| اللغة: | English |
| تدمد: | 1540-8167 |
| DOI: | 10.1111/jce.15714 |
| الاتاحة: | https://tud.qucosa.de/id/qucosa%3A89625 https://tud.qucosa.de/api/qucosa%3A89625/attachment/ATT-0/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.DRESDEN.oai.qucosa.de.qucosa.89625 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| تدمد: | 15408167 |
|---|---|
| DOI: | 10.1111/jce.15714 |