Academic Journal
From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis
| العنوان: | From Stable to Lab—Investigating Key Factors for Sudden Deaths Caused by Streptococcus suis |
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| المؤلفون: | Hennig-Pauka, Isabel, Imker, Rabea, Mayer, Leonie, Brügmann, Michael, Werckenthin, Christiane, Weber, Heike, Menrath, Andrea, de Buhr, Nicole |
| Publication Status: | publishedVersion |
| بيانات النشر: | MDPI, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Original Material: | urn:nbn:de:bsz:15-qucosa2-846517 |
| مصطلحات موضوعية: | Streptococcus suis, sudden death, DIC, NETs, immune reaction, info:eu-repo/classification/ddc/570, ddc:570 |
| الوصف: | Swine stocks are endemically infected with the major porcine pathogen Streptococcus (S.) suis. The factors governing the transition from colonizing S. suis residing in the tonsils and the exacerbation of disease have not yet been elucidated. We analyzed the sudden death of fattening pigs kept under extensive husbandry conditions in a zoo. The animals died suddenly of septic shock and showed disseminated intravascular coagulopathy. Genotypic and phenotypic characterizations of the isolated S. suis strains, a tonsillar isolate and an invasive cps type 2 strain, were conducted. Isolated S. suis from dead pigs belonged to cps type 2 strain ST28, whereas one tonsillar S. suis isolate harvested from a healthy animal belonged to ST1173. Neither S. suis growth, induction of neutrophil extracellular traps, nor survival in blood could explain the sudden deaths. Reconstituted blood assays with serum samples from pigs of different age groups from the zoo stock suggested varying protection of individuals against pathogenic cps type 2 strains especially in younger pigs. These findings highlight the benefit of further characterization of the causative strains in each case by sequence typing before autologous vaccine candidate selection. |
| Original Identifier: | oai:qucosa:de:qucosa:84651 |
| نوع الوثيقة: | Article |
| اللغة: | English |
| تدمد: | 2076-0817 |
| Relation: | 249 |
| الاتاحة: | https://ul.qucosa.de/id/qucosa%3A84651 https://ul.qucosa.de/api/qucosa%3A84651/attachment/ATT-0/ |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.DRESDEN.oai.qucosa.de.qucosa.84651 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
Full Text Finder | تدمد: | 20760817 |
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