Academic Journal
Efficacy and Safety of Albumin-bound Paclitaxel in Treating Recurrent Advanced Non-small Cell Lung Cancer
| العنوان: | Efficacy and Safety of Albumin-bound Paclitaxel in Treating Recurrent Advanced Non-small Cell Lung Cancer |
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| المؤلفون: | Puyuan XING, Junling LI, Yuankai SHI |
| المصدر: | Chinese Journal of Lung Cancer, Vol 16, Iss 10, Pp 519-523 (2013) |
| بيانات النشر: | Chinese Anti-Cancer Association; Chinese Antituberculosis Association, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Lung neoplsms, Sunitinib, Recurrence, Tyrosine kinase inhibitors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Background and objective Advanced non-small cell lung cancer (NSCLC) is a common malignancy that is incurable. No standard treatment exists for recurrent patients. This article analyzed the efficacy and safety of sunitinib (37.5 mg qd) on a continuous daily dosing (CDD) schedule in treating recurrent advanced NSCLC. Methods We retrospectively analyzed the short-term efficacy and toxicity of sunitinib CDD in treating 17 patients who had previously undergone multiple cycles of therapy for advanced NSCLC in our hospital from January 2011 to December 2012. Treatment-related survival was also analyzed. Results Among the 17 patients, the best overall response was partial response in 1 patient (5.9%), stable disease in 7 patients (41.2%), and progressive disease in 9 patients (52.9%). The overall response rate was 5.9%, and the disease control rate was 47.1%. The median progression-free survival was 4.4 months (95%CI: 4.05-7.46). The main grade 3/4 toxicity was hand-foot skin reaction. Conclusion Sunitinib (37.5 mg QD) CDD enabled good objective response in advanced NSCLC patients who had previously received multiple cycles of treatment and was well tolerated. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1009-3419 1999-6187 |
| Relation: | https://doaj.org/toc/1009-3419; https://doaj.org/toc/1999-6187 |
| DOI: | 10.3779/j.issn.1009-3419.2013.10.04 |
| URL الوصول: | https://doaj.org/article/ffb27ee65d26430d85ab9a5ae9694f4f |
| رقم الانضمام: | edsdoj.ffb27ee65d26430d85ab9a5ae9694f4f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10093419 19996187 |
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| DOI: | 10.3779/j.issn.1009-3419.2013.10.04 |